Tranfusion side effects
Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 5 November 2011, last major update September 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.
● Chimerism: presence of more than one genetically distinct population of cells in a single organism
● Microchimerism: stable persistence of an allogeneic cell population, representing <5% of circulating cells in an individual
● Due to transplantation, pregnancy or transfusion (Semin Hematol 2007;44:24)
● Present in 50% of transfused, severely injured patients at hospital discharge (J Trauma 2004;57:702)
● Injury induces immunosuppressive milieu, leading to persistence of donor WBCs
● Not affected by leukoreduction (Transfusion 2006;46:1863)
● No apparent increased risk of transfusion associated graft versus host disease (Blood 2001;98:272)
● No adverse effects, so not recommended to modify transfusion guidelines or practices
● Can be prevented by irradiation, but microchimerism is NOT an indication for irradiation
End of Transfusion Medicine > Tranfusion side effects > Microchimerism
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).