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Transfusion medicine

Tranfusion side effects

Microchimerism

Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 5 November 2011, last major update September 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.

General
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● Chimerism: presence of more than one genetically distinct population of cells in a single organism
● Microchimerism: stable persistence of an allogeneic cell population, representing <5% of circulating cells in an individual
● Due to transplantation, pregnancy or transfusion (Semin Hematol 2007;44:24)
● Present in 50% of transfused, severely injured patients at hospital discharge (J Trauma 2004;57:702)
● Injury induces immunosuppressive milieu, leading to persistence of donor WBCs
● Not affected by leukoreduction (Transfusion 2006;46:1863)
● No apparent increased risk of transfusion associated graft versus host disease (Blood 2001;98:272)

Clinical features
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● No adverse effects, so not recommended to modify transfusion guidelines or practices
● Can be prevented by irradiation, but microchimerism is NOT an indication for irradiation

End of Transfusion Medicine > Tranfusion side effects > Microchimerism

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