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Transfusion medicine

Tranfusion-transmitted disease

Pathogen inactivation and transfusion

Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 6 November 2011, last major update September 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.

General
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● Additional layer of protection from known and unknown infectious agents (Semin Hematol 2007;44:32), such as leukoreduction (filtration), chemicals and mechanical agents (heat, radiation, fractionation)
● Techniques may damage blood products or have their own side effects
● Examples: Methylene blue for fresh frozen plasma (Vox Sang 2007;92:319), photochemical treatment with amotosalen and ultraviolet A for parvovirus B19 (Transfusion 2007;47:1062), S-303 for red cells (Transfusion 2006;46:1778)

Additional references
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● Arch Pathol Lab Med 2007;131:719, Transfus Apher Sci 2006;35:189, Transfus Apher Sci 2006;35:83 (plasma), Best Pract Res Clin Haematol 2006;19:205

End of Transfusion Medicine > Tranfusion-transmitted disease > Pathogen inactivation and transfusion

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