Transfusion medicine
Tranfusion transmitted disease
Pathogen inactivation and transfusion

Topic Completed: 1 September 2011

Minor changes: 5 April 2019

Copyright: 2002-2017,, Inc.

PubMed Search: Pathogen inactivation and transfusion [title]

Huy Phu Pham, M.D., M.P.H.
Page views in 2019: 13
Page views in 2020 to date: 11
Cite this page: Pham H. Pathogen inactivation and transfusion . website. Accessed May 30th, 2020.
Definition / general
  • Additional layer of protection from known and unknown infectious agents (Semin Hematol 2007;44:32), such as leukoreduction (filtration), chemicals and mechanical agents (heat, radiation, fractionation)
  • Techniques may damage blood products or have their own side effects
  • Examples: methylene blue for fresh frozen plasma (Vox Sang 2007;92:319), photochemical treatment with amotosalen and ultraviolet A for parvovirus B19 (Transfusion 2007;47:1062), S-303 for red cells (Transfusion 2006;46:1778)
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