Transfusion medicine
Tranfusion transmitted disease
Pathogen inactivation and transfusion

Author: Huy Phu Pham, M.D. (see Authors page)

Revised: 27 October 2017, last major update September 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pathogen inactivation and transfusion [title]

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Cite this page: Pham, H.P. Pathogen inactivation and transfusion . website. Accessed January 19th, 2019.
Definition / general
  • Additional layer of protection from known and unknown infectious agents (Semin Hematol 2007;44:32), such as leukoreduction (filtration), chemicals and mechanical agents (heat, radiation, fractionation)
  • Techniques may damage blood products or have their own side effects
  • Examples: methylene blue for fresh frozen plasma (Vox Sang 2007;92:319), photochemical treatment with amotosalen and ultraviolet A for parvovirus B19 (Transfusion 2007;47:1062), S-303 for red cells (Transfusion 2006;46:1778)