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Transfusion medicine

Tranfusion-transmitted disease

SEN-V virus


Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 6 November 2011, last major update October 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.

General
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● SEN-V virus is a blood-borne, single stranded, nonenveloped DNA virus
● Discovered in 1999 in Italy, distantly related to transfusion transmitted virus (Infect Dis 2001;183:359)

Prevalence varies by region:
● 1.8% in the US
● 10-22% in Japan
● 15% in Taiwan
● 5% in Thailand
● 8-17% in Germany
● 24% in Greece
● At least 13% in Italy
● Present in 40% of hemodialysis patients in Poland (Wiad Lek 2006;59:751)
● Frequently occurs early in life; in eastern Taiwan, present in 25-31% of adolescents, may be associated with urbanization, probably not parenteral transmission in this group (J Gastroenterol Hepatol 2007;22:171)
● Prevalence increases with transfusions (Pediatr Infect Dis J 2006;25:390)
● Detected in as many as 30% of postoperative transfusion recipients (vs. 3% postoperative patients who did not receive transfusions)

● SEN-V virus consists of 8 strains, A-H
● Strains D and H appear to be associated with non A-E hepatitis
● Also found in 30% of cases of transfusion-associated non A-E hepatitis in US (vs. 1.8% of healthy blood donors), but overall, considered to have weak association, at most, with hepatitis (Minerva Gastroenterol Dietol 2002;48:73, Transfusion 2005;45:1084)
● High levels are associated with poor survival in HIV+ patients (AIDS 2005;19:1091)

End of Transfusion Medicine > Tranfusion-transmitted disease > SEN-V virus


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