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Transfusion medicine

Tranfusion-transmitted disease

Syphilis


Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 6 November 2011, last major update October 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.

General
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● No cases of transfusion transmitted syphilis in US since 1966
● Detected by serologic testing, although blood with positive test in US is unlikely to be infectious (Transfusion 2002;42:94)
● 1,200 cases detected in US donors during 1995-2000 (J Infect Dis 2002;185:545)
● Test may contribute little to transfusion safety (NIH Consensus Report), although some consider it a marker (although nonspecific) for high risk behavior associated with other sexually transmitted diseases

Donor positive rates:
● Brazil - 3% (Sex Transm Dis 2001;28:710)
● Cameroon - 9% (Transfus Med 2003;13:267)
● Tanzania - 13% (East Afr Med J 1999;76:167)
● Turkey - 0.2% (Mikrobiyol Bul 2004;38:445)

● Can be transmitted by blood transfusion; refrigeration kills most (but not all) spirochetes within 1-2 days, but platelets are stored at room temperature and some red cells are transfused immediately without refrigeration

End of Transfusion Medicine > Tranfusion-transmitted disease > Syphilis


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