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WHO/ISUP classification

Flat lesions with atypia

Reviewers: Sean Williamson, M.D. (see Reviewers page)
Revised: 2 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


Reactive atypia:
● Inflammatory atypia
● Uniformly enlarged and vesicular nuclei, central prominent nucleoli, may have frequent mitotic figures
● May have history of instrumentation, stones or therapy
● Not neoplastic

Atypia (flat) of unknown significance:
● Between reactive atypia and dysplasia, more pleomorphism and hyperchromasia than expected for the amount of inflammation present
● Should have close follow up and reevaluation after inflammation subsides
● In the bladder, some authors have recommend combining this category with reactive atypia since it is not clearly associated with adverse consequences

End of Ureters > WHO/ISUP classification> Flat lesions with atypia

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