WHO / ISUP classification

Author: Sean Williamson, M.D. (see Authors page)

Revised: 8 Septembver 2017, last major update June 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Ureters hyperplasia [title]

Table of Contents
Definition / general
Cite this page: Williamson, S. Hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uretershyperplasia.html. Accessed July 21st, 2018.
Definition / general
  • Flat hyperplasia:
    • Markedly thickened mucosa without cytologic atypia
    • May be adjacent to low grade papillary urothelial neoplasm
    • By itself has no malignant potential and requires no treatment
  • Papillary hyperplasia:
    • Slight tenting, undulating or papillary growth lined by urothelium of varying thickness without atypia
    • Asymptomatic, found on routine follow up cystoscopy of papillary urothelial neoplasms
    • Often has small dilated capillaries at base but no well defined fibrovascular core
    • Lacks discrete papillary fronds associated with papillary neoplasm
    • Treatment: Follow up if new, unknown if increased risk of papillary neoplasm in patient with prior history of papillary urothelial tumor
  • Papillary hyperplasia with atypia:
    • Architectural pattern of papillary hyperplasia with atypia of overlying urothelium
    • 80% male, age range 55 to 92 years
    • At diagnosis, 50% associated with flat carcinoma in situ, 30% with dysplasia
    • Prognostic implications: usually associated with high grade papillary urothelial carcinoma; also CIS and invasive urothelial carcinoma (Hum Pathol 2002;33:512)