Obstructive lesions

Author: Sean Williamson, M.D. (see Authors page)

Revised: 7 September 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Ureters obstructive lesions

Cite this page: Williamson, S. Obstructive lesions. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uretersobstruct.html. Accessed December 11th, 2018.
Definition / general
  • Intrinsic:
    • Stones ( ≤ 5 mm), usually lodge at (a) ureteropelvic junction, (b) where ureters cross iliac artery and (c) where ureters enter bladder
    • Strictures (congenital or due to sclerosing retroperitoneal fibrosis)
    • Tumors, blood clots, neurogenic causes
  • Extrinsic:
    • Pregnancy, local inflammation, endometriosis, local tumors (ureteral obstruction is a major cause of death from cervical carcinoma)
  • Sclerosing retroperitoneal fibrosis:
    • Adults 40+
    • 70% idiopathic; others associated with ergot derivatives, beta blockers, adjacent inflammation, local tumors
    • Associated with mediastinal fibrosis, sclerosing cholangitis, Riedel thyroiditis
    • May have autoimmune origin, related to the spectrum of IgG4 associated disease (case report of 39 year old man, Pathol Res Pract 2011;207:712)
Microscopic (histologic) description
  • Lymphocytes, plasma cells, eosinophils
  • Variable granulomatous inflammation