Urethra
General
Clear cell adenocarcinoma

Reviewers: Turki Al-Hussain, M.D. (see Authors page)

Revised: 3 May 2016, last major update June 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Clear cell adenocarcinoma urethra
Cite this page: Clear cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/urethraclearcell.html. Accessed October 21st, 2017.
Definition / general
  • Usually women, mean age 58
  • Similar clinical presentation to other urethral carcinomas
  • Thought to arise from surface urotheilal metaplasia, or Mllerian rests or Mllerianosis
  • Case reports
  • 82 year old woman with urethral mass (Case of the Week #194)
  • Gross description
  • Often (56%) arises within a urethral diverticulum
  • Gross images

    Images hosted on PathOut server:

    Contributed by Dr. Jesus Chavez and Dr. Debra Zynger, The Ohio State University / Wexner Medical Center (USA):

    Female, urethra and bladder, clear cell adenocarcinoma

    Microscopic (histologic) description
  • Similar to clear cell adenocarcinoma of female genital tract
  • Tubulocystic, papillary, and diffuse patterns
  • Hobnail and flattened cells with abundant clear cytoplasm
  • Moderate to marked nuclear pleomorphism
  • Frequent mitotic figures
  • Microscopic (histologic) images

    Images hosted on PathOut server:

    Contributed by Dr. Jesus Chavez and Dr. Debra Zynger, The Ohio State University / Wexner Medical Center (USA):

    Solid and nested growth pattern

    Tubulocystic growth pattern

    Extracellular mucoid material

    Vacuolated cytoplasm and hyperchromatic nuclei



    Case of the Week #194:

    H&E


    CK7

    CD15

    Ki-67

    p53

    Positive stains
  • PAX2, PAX8
  • Negative stains
  • PSA, PAP
  • Secondary involvement from female genital tract should be excluded
  • Differential diagnosis
  • Nephrogenic adenoma: no marked nuclear pleomorphism, no mitotic figures, no infiltrative or solid growth pattern
  • Additional references