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Urethra

Melanoma

Reviewers: Turki Al-Hussain, M.D. (see Reviewers page)
Revised: 3 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Adults, mean age 73 years
● Urethra is the most common site of origin of malignant melanoma in the urinary tract
● Usually involves distal urethra in men and women
● Less common in bladder
● 5 year survival ~ 20% (may die of unrelated causes, Am J Surg Pathol 2000;24:785)

Treatment
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● Total urethrectomy plus bilateral inguinal node dissection

Gross description
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● Polypoid, mean 2.6 cm

Micro description
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● Vertical growth phase often has prominent nodular component
● Also radial growth phase
● Abundant eosinophilic cytoplasm with large nuclei and prominent nucleoli
● Numerous mitoses
● Melanin pigment usually present, but often focal

Differential diagnosis
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● Urothelial carcinoma
● Sarcomatoid carcinoma

End of Urethra > Melanoma

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