Topic Completed: 1 June 2012

Revised: 20 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Urethra melanoma "loattrfree full text"[sb]
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Cite this page: Al-Hussain T. Melanoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/urethramelanoma.html. Accessed March 21st, 2019.
Definition / general
  • Adults, mean age 73 years
  • Urethra is the most common site of origin of malignant melanoma in the urinary tract
  • Usually involves distal urethra in men and women
  • Less common in bladder
  • 5 year survival ~20% (may die of unrelated causes, Am J Surg Pathol 2000;24:785)
  • Total urethrectomy plus bilateral inguinal node dissection
Gross description
  • Polypoid, mean 2.6 cm
Microscopic (histologic) description
  • Vertical growth phase often has prominent nodular component
  • Also radial growth phase
  • Abundant eosinophilic cytoplasm with large nuclei and prominent nucleoli
  • Numerous mitoses
  • Melanin pigment usually present but often focal
Differential diagnosis
  • Sarcomatoid carcinoma
  • Urothelial carcinoma
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