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Urethra

Normal

Reviewers: Turki Al-Hussain, M.D. (see Reviewers page)
Revised: 3 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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Males:
● Consists of mucosa, submucosa, surrounding corpus spongiosum
● Male urethra is 15–20 cm long and is divided into three anatomic segments:
          1. Prostatic urethra lined by urothelium
          2. Bulbomembranous/membranous urethra lined by pseudostratified or stratified columnar epithelium
          3. Penile urethra lined by pseudostratified or stratified columnar epithelium
● Meatal and parameatal urethra lined by nonkeratinizing squamous epithelium
● Cowper's glands: small paired bulbomembranous urethral glands on left and right side of membranous urethra
● Littré glands: scattered mucus-secreting periurethral glands at periphery of penile urethra except anteriorly

Females:
● Epithelium supported by connective tissue, surrounded by longitudinal smooth muscle continuous with bladder
● Urethra continuous with vaginal wall
● Distal 2/3 lined by nonkeratinizing squamous epithelium, proximal 1/3 lined by urothelium
● Skene’s glands: concentrated near meatus but found throughout urethra; periurethral glands lined by pseudostratified and stratified columnar epithelium

References
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● Urologic Surgical Pathology, 2nd Edition, By David G. Bostwick, MD, MBA, FCAP and Liang Cheng, MD

End of Urethra > Normal

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