Stromal tumors
Endometrial stromal sarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 May 2017, last major update January 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: endometrial stromal sarcoma [title] uterus

Related topics: Low grade endometrial stromal sarcoma, Undifferentiated endometrial stromal sarcoma

Cite this page: Endometrial stromal sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusESS.html. Accessed December 16th, 2018.
Definition / general
  • 0.2% to 1.5% of uterine malignancies; < 10% of uterine sarcomas
  • Low grade or high grade
Diagrams / tables

Images hosted on PathOut server:

Diagnostic algorithm for uterine
pure mesenchymal neoplasms
need not count mitotic figures

Gross images

Images hosted on other servers:

Lobulated white fleshy tumor

Microscopic (histologic) description
  • Resembles endometrial stromal nodules but with infiltration, defined as irregular, jagged islands or tongues of neoplastic stromal cells between smooth muscle bundles of the surrounding normal myometrium
  • May have angiolymphatic invasion (clumps of tumor cells present in spaces within the myometrium)
  • May have glands without cuff of hypercellular stroma seen in adenosarcoma
Positive stains