Stromal tumors
Endometrial stromal sarcoma

Topic Completed: 1 January 2012

Revised: 25 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: endometrial stromal sarcoma [title] uterus

Related topics: Low grade endometrial stromal sarcoma, Undifferentiated endometrial stromal sarcoma

Nat Pernick, M.D.
Page views in 2018: 13,207
Page views in 2019 to date: 8,644
Cite this page: Pernick N. Endometrial stromal sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusESS.html. Accessed October 19th, 2019.
Definition / general
  • 0.2% to 1.5% of uterine malignancies; < 10% of uterine sarcomas
  • Low grade or high grade
Diagrams / tables

Images hosted on PathOut server:

Diagnostic algorithm for uterine
pure mesenchymal neoplasms
need not count mitotic figures

Gross images

Images hosted on other servers:

Lobulated white fleshy tumor

Microscopic (histologic) description
  • Resembles endometrial stromal nodules but with infiltration, defined as irregular, jagged islands or tongues of neoplastic stromal cells between smooth muscle bundles of the surrounding normal myometrium
  • May have angiolymphatic invasion (clumps of tumor cells present in spaces within the myometrium)
  • May have glands without cuff of hypercellular stroma seen in adenosarcoma
Positive stains
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