Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Uterus

Stromal tumors

Uterine tumors resembling ovarian sex cord tumors


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 November 2011, last major update October 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
=========================================================================

● Rare tumors of uncertain etiology
● Most are benign with uniform cells, no infiltration and low mitotic index
● Malignant variants behave similar to low grade stromal sarcoma (may recur or metastasize)

Case reports
=========================================================================

● 62 year old woman with recurrent postmenopausal bleeding and uterine polyp (Cases J 2009;2:55)

Micro description
=========================================================================

● More cellular than endometrial stromal nodules, mature smooth muscle often present
● Sex cord-like elements are cords, tubules or sheets resembling epithelial cells, but with scanty cytoplasm, indistinct cell margins and round nuclei
● May have abundant eosinophilic or clear cytoplasm
● No prominent arterioles

Micro images
=========================================================================



Tumor cells resemble granulosa cells

    

              
Various images

Positive stains
=========================================================================

● Often co-express sex cord (inhibin, calretinin, WT1, melanA), epithelial (KL1, EMA) and smooth muscle markers (smooth muscle actin, desmin, histone deacetylase 8), but variable staining for all markers (Am J Surg Pathol 2010;34:1749, Mod Pathol 2006;19:17)
● Also variable staining for CD10, CD117

Negative stains
=========================================================================

● HMB45

EM description
=========================================================================

● Polyphenotypic neoplasms with focal epithelial and variable sex cord-like differentiation, but no smooth muscle differentiation (Ultrastruct Pathol 2010;34:16)

Differential diagnosis
=========================================================================

Endometrial stromal tumor: 60% have JAZF1-JJAZ1 gene fusion, not present in UTROSCT (Am J Surg Pathol 2009;33:1206)
● Vascular leiomyoma with plexiform pattern (Ann Diagn Pathol 2010;14:355) or leiomyoma with tubules (Int Semin Surg Oncol 2008;5:15)

End of Uterus > Stromal tumors > Uterine tumors resembling ovarian sex cord tumors


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).