Home Chapter Home Jobs Conferences Fellowships Books
Advertisement
Uterus
Stromal tumors
Adenosarcoma with stromal overgrowth
Reviewer: Sanjay Logani, M.D., InCyte Pathology (see Reviewers page)
Revised: 21 September 2012, last major update June 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
=========================================================================
● Typical adenosarcoma overgrown by pure sarcoma that accounts for at least 25% of the tumor
Terminology
=========================================================================
● Also called adenosarcoma with sarcomatous overgrowth
Clinical features
=========================================================================
● Occurs in 1/3 of adenosarcomas (Am J Surg Pathol 2009;33:278)
● Aggressive, 45%-70% recur, usually in pelvis
● Patients may develop metastases and die of disease (Am J Surg Pathol 1989;13:28)
Case reports
=========================================================================
● 47 year old woman with mass protruding through os (The Internet Journal of Pathology 2009 Volume 8 Number 1)
● 52 year old woman post-tamoxifen for breast cancer (Rev Hosp Clin Fac Med Sao Paulo 2000;55:17)
Gross images
=========================================================================
Post-tamoxifen for breast cancer
Micro description (Histopathology)
=========================================================================
● Typical adenosarcoma overgrown by pure sarcoma that accounts for at least 25% of the tumor
● Resembles malignant phylloides tumor
● May have heterologous sarcoma component; rhabdomyosarcoma is most common
Micro images
=========================================================================
AFIP #200: Pure sarcomatous component extends from the few benign glands
AFIP #201: Pure sarcoma invades the myometrium at the base of this tumor
AFIP #202: Venous invasion by the stromal component
Virtual slides
=========================================================================
Colonic tumor
Positive stains
=========================================================================
● Ki-67, p53
Negative stains
=========================================================================
● CD10, ER (Am J Surg Pathol 2008;32:1013)
End of Uterus > Stromal tumors > Adenosarcoma with stromal overgrowth
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).