Adenosarcoma with stromal overgrowth

Uterus
Stromal tumors
Adenosarcoma with stromal overgrowth

Author: Sanjay Logani, M.D. (see Authors page)

Revised: 26 January 2017, last major update June 2010

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: adenosarcoma with stromal overgrowth

Table of Contents

Cite this page: Adenosarcoma with stromal overgrowth. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusadenosarcomaovergrowth.html. Accessed July 16th, 2017.

Definition / general

Typical adenosarcoma overgrown by pure sarcoma that accounts for at least 25% of the tumor

Terminology

Also called adenosarcoma with sarcomatous overgrowth

Clinical features

Occurs in 1/3 of adenosarcomas (Am J Surg Pathol 2009;33:278)
Aggressive, 45% - 70% recur and usually in pelvis
Patients may develop metastases and die of disease (Am J Surg Pathol 1989;13:28)

Case reports

47 year old woman with amenorrhea and mass protruding through os (The Internet Journal of Pathology 2009;8:1)
52 year old woman post-tamoxifen for breast cancer (Rev Hosp Clin Fac Med Sao Paulo 2000;55:17)

Microscopic (histologic) description

Typical adenosarcoma overgrown by pure sarcoma that accounts for at least 25% of the tumor
Resembles malignant phylloides tumor
May have heterologous sarcoma component; rhabdomyosarcoma is most common

Positive stains

Ki67, p53

Negative stains

CD10, ER (Am J Surg Pathol 2008;32:1013)