Adenosquamous carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 January 2017, last major update October 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: adenosquamous carcinoma uterus

Cite this page: Adenosquamous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusadenosquamous.html. Accessed July 17th, 2018.
Definition / general
  • Endometrioid adenocarcinoma with malignant appearing squamous elements representing at least 10% of tumor
  • Adenoacanthoma and adenosquamous carcinoma may represent a continuum of squamous metaplasia
Clinical features
  • Similar prognosis as adenocarcinoma when compared by stage and grade (i.e. squamous component does not affect prognosis)
Case reports
  • 72 year old woman with tumor containing osteoclast-like giant cells (APMIS 2005;113:140)
Microscopic (histologic) description
  • Squamous component should be definite, based on keratinization, intercellular bridges or 3 out of these 4 criteria:
    • (a) sheet-like growth without gland formation or palisading,
    • (b) sharp cell margins,
    • (c) eosinophilic and thick or glassy cytoplasm, and
    • (d) a decreased nuclear:cytoplasmic ratio compared with foci elsewhere in the same tumor)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Differential diagnosis