Adenosquamous carcinoma

Topic Completed: 1 October 2011

Revised: 25 February 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed search: adenosquamous carcinoma uterus

Nat Pernick, M.D.
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Cite this page: Pernick N. Adenosquamous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusadenosquamous.html. Accessed August 24th, 2019.
Definition / general
  • Endometrioid adenocarcinoma with malignant appearing squamous elements representing at least 10% of tumor
  • Adenoacanthoma and adenosquamous carcinoma may represent a continuum of squamous metaplasia
Clinical features
  • Similar prognosis as adenocarcinoma when compared by stage and grade (i.e. squamous component does not affect prognosis)
Case reports
  • 72 year old woman with tumor containing osteoclast-like giant cells (APMIS 2005;113:140)
Microscopic (histologic) description
  • Squamous component should be definite, based on keratinization, intercellular bridges or 3 out of these 4 criteria:
    • (a) sheet-like growth without gland formation or palisading,
    • (b) sharp cell margins,
    • (c) eosinophilic and thick or glassy cytoplasm, and
    • (d) a decreased nuclear:cytoplasmic ratio compared with foci elsewhere in the same tumor)
Microscopic (histologic) images

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Various images

Positive stains
Differential diagnosis
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