Uterus - Adenosquamous carcinoma

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Uterus

Endometrial carcinoma

Adenosquamous carcinoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 October 2011, last major update October 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Endometrioid adenocarcinoma with malignant appearing squamous elements representing at least 10% of tumor
● Adenoacanthoma and adenosquamous carcinoma may represent a continuum of squamous metaplasia

Clinical features
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● Similar prognosis as adenocarcinoma when compared by stage and grade (i.e. squamous component does not affect prognosis)

Case report
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● 72 year old woman with tumor containing osteoclast-like giant cells (APMIS 2005;113:140)

Micro description
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● Squamous component should be definite, based on keratinization, intercellular bridges or 3 out of these 4 criteria: (a) sheet-like growth without gland formation or pallisading, (b) sharp cell margins, (c) eosinophilic and thick or glassy cytoplasm, and (d) a decreased nuclear:cytoplasmic ratio compared with foci elsewhere in the same tumor)

Micro images
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Various images

Positive stains
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● CD44 in squamous component (Arch Pathol Lab Med 2000;124:212)

Differential diagnosis
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● Extension of cervical tumor (Int J Gynecol Cancer 2004;14:625)

End of Uterus > Endometrial carcinoma > Adenosquamous carcinoma

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