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Table of Contents
Definition / general | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Adenosquamous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusadenosquamous.html. Accessed July 16th, 2017.
Definition / general
- Endometrioid adenocarcinoma with malignant appearing squamous elements representing at least 10% of tumor
- Adenoacanthoma and adenosquamous carcinoma may represent a continuum of squamous metaplasia
Clinical features
- Similar prognosis as adenocarcinoma when compared by stage and grade (i.e. squamous component does not affect prognosis)
Case reports
- 72 year old woman with tumor containing osteoclast-like giant cells (APMIS 2005;113:140)
Microscopic (histologic) description
- Squamous component should be definite, based on keratinization, intercellular bridges or 3 out of these 4 criteria:
- (a) sheet-like growth without gland formation or palisading,
- (b) sharp cell margins,
- (c) eosinophilic and thick or glassy cytoplasm, and
- (d) a decreased nuclear:cytoplasmic ratio compared with foci elsewhere in the same tumor)
Microscopic (histologic) images
Images hosted on other servers:
Various images
Positive stains
- CD44 in squamous component (Arch Pathol Lab Med 2000;124:212)
Differential diagnosis
- Extension of cervical tumor (Int J Gynecol Cancer 2004;14:625)
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