Non tumor
Arias-Stella reaction

Author: Nat Pernick, M.D. (see Authors page)

Revised: 12 January 2017, last major update September 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: Arias-Stella reaction uterus

Cite this page: Arias-Stella reaction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusariasstella.html. Accessed February 22nd, 2017.
Definition / General
  • See also Cervix-cytology topic
  • Hormonally induced histologic changes seen with intrauterine pregnancy, ectopic pregnancy and progesterone therapy (Adv Anat Pathol 2002;9:12)
  • First described in 1954 paper by Peruvian pathologist
  • Exaggerated gestational hyperplasia
  • Endometrial glands are enlarged with abundant clear or eosinophilic cytoplasm and marked nuclear changes (large, hyperchromatic, pleomorphic and smudged) with rare mitotic figures
  • Decidualized stroma
  • Changes usually focal, may occur in cervix, endocervical polyps, adenomyosis (Acta Obstet Gynecol Scand 2007;86:106), endometriosis (Int J Gynecol Pathol 2010;29:185), post abortion curettings (20% - 70%), pregnancies, moles and choriocarcinoma (endometrial nuclei may be gigantic in moles and choriocarcinoma)
  • May provide initial information of ectopic pregnancy (Arch Gynecol Obstet 2007;276:47)
Micro Images

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Negative Stains
Differential Diagnosis