Non tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 January 2017, last major update December 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: atrophy [title] uterus

Cite this page: Atrophy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusatrophy.html. Accessed November 12th, 2018.
Definition / general
  • Normal in prepubertal girls, perimenopausal or menopausal women
Clinical features
Gross images

Images hosted on other servers:

Endometrial atrophy

Microscopic (histologic) description
  • Low cuboidal or columnar epithelium with no mitotic figures
  • Glands usually tubular or cystic, may be closely packed
  • Stroma appears inactive with variable collagenization and minimal mitotic activity
Microscopic (histologic) images

Images hosted on PathOut server:

Simple atrophy: this hysterectomy specimen from a postmenopausal woman
contains a thin endometrium with only a few residual glands surrounded by an atrophic,
somewhat fibrotic stroma; the junction between endometrium and myometrium
is not sharply defined, and the underlying myometrium also appears atrophic

Cystic atrophy: this photomicrograph shows most of the specimen
obtained at curettage from a postmenopausal woman who presented with
vaginal bleeding; the glands vary from small to cystically dilated, but all
are lined by a single layer of epithelial cells that are cuboidal to flattened


Histopathology Endometrium - Senile atrophySenile atrophy
Differential diagnosis
  • Basalis endometrium, lower uterine segment, endometrial lining of submucous myoma, polyp, progesterone effect