Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 7 December 2011, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Normal in prepubertal girls, perimenopausal or menopausal women
● Cystic atrophy is associated with postmenopausal tamoxifen for breast cancer (Am J Obstet Gynecol 1998;178:1145)
● Low cuboidal or columnar epithelium with no mitotic figures
● Glands usually tubular or cystic, may be closely packed
● Stroma appears inactive with variable collagenization and minimal mitotic activity
Simple atrophy: This hysterectomy specimen from a postmenopausal woman contains a thin endometrium with only a few residual glands surrounded by an atrophic, somewhat fibrotic stroma. The junction between endometrium and myometrium is not sharply defined, and the underlying myometrium also appears atrophic
Cystic atrophy: This photomicrograph shows most of the specimen obtained at curettage from a postmenopausal woman who presented with vaginal bleeding. The glands vary from small to cystically dilated, but all are lined by a single layer of epithelial cells that are cuboidal to flattened
Atrophy post-tamoxifen therapy
● Senile atrophy
● Basalis endometrium, lower uterine segment, endometrial lining of submucous myoma, polyp, progesterone effect
End of Uterus > Non tumor > Atrophy
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