Uterus
Non tumor
Disordered proliferative endometrium



Topic Completed: 1 November 2011

Revised: 21 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed search: disordered proliferative endometrium

Nat Pernick, M.D.
Page views in 2018: 19,891
Page views in 2019 to date: 10,609
Cite this page: Pernick N. Disordered proliferative endometrium. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusdisorderedproliferative.html. Accessed June 24th, 2019.
Definition / general
  • Associated with anovulatory cycles, exogenous estrogen therapy; common in perimenopausal and menopausal women
  • Difficult to make this diagnosis on biopsy
  • Sternberg indicates this diagnosis is "insufficient for diagnosis of hyperplasia," although WHO calls it a form of simple hyperplasia
Microscopic (histologic) description
  • Reflects unopposed estrogen stimulation (i.e. no subsequent progesterone stimulation)
  • Resembles normal exuberant proliferative endometrium, but without uniform glandular development (some glands cystically dilated, others have shallow budding)
  • Increase of cystically dilated glands, but relatively normal ratio of glands to stroma
  • Part of a continuum with endometrial hyperplasia
  • Metaplastic changes (ciliated epithelium) are common
  • May see endometrial breakdown and hemorrhage with thrombosed, thin walled vessels
  • Often plasma cells, but no clinical evidence of infection (Hum Pathol 2007;38:581)
Microscopic (histologic) images

Images hosted on other servers:

Scattered cystically
dilated glands but a low
gland density overall

Back to top