Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Non tumor

Disordered proliferative hyperplasia

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 4 December 2011, last major update November 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Associated with anovulatory cycles, exogenous estrogen therapy; common in perimenopausal and menopausal women
● Difficult to make this diagnosis on biopsy
● Sternberg indicates this diagnosis is “insufficient for diagnosis of hyperplasia”, although WHO calls it a form of simple hyperplasia

Micro description

● Reflects unopposed estrogen stimulation (i.e. no subsequent progesterone stimulation)
● Resembles normal exuberant proliferative endometrium, but without uniform glandular development (some glands cystically dilated, others have shallow budding)
● Increase of cystically dilated glands, but relatively normal ratio of glands to stroma
● Part of a continuum with endometrial hyperplasia
● Metaplastic changes (ciliated epithelium) are common
● May see endometrial breakdown and hemorrhage with thrombosed, thin walled vessels
● Often plasma cells, but no clinical evidence of infection (Hum Pathol 2007;38:581)

Micro images

Scattered cystically dilated glands but a low gland density overall

End of Uterus > Non tumor > Disordered proliferative hyperplasia

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).