Non tumor
Dyssynchronous endometrium

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 January 2017, last major update December 2011

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PubMed search: dyssynchronous endometrium

Cite this page: Dyssynchronous endometrium. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusdyssynchronous.html. Accessed July 19th, 2018.
Definition / general
  • Discordance between glands and stroma, both usually in secretory phasel
  • Also defined as endometrial glandular dating lagging both chronological and stromal dating by 3+ days
  • Also proliferative endometrium and secretory stroma
  • Often due to dysfunctional uterine bleeding (DUB)
  • DUB patients lack cyclic endometrial stimulation; instead have constant unopposed estrogen production with continuous endometrial stimulation; endometrium outgrows its blood supply, leading to tissue breakdown and sloughing
  • Healing of this endometrium is irregular and dyssynchronous (eMedicine)
Microscopic (histologic) images

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Dyssynchronous endometrium