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Uterus

Non tumor

Dyssynchronous endometrium


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 19 February 2012, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Discordance between glands and stroma, both usually in secretory phasel
● Also defined as endometrial glandular dating lagging both chronological and stromal dating by 3+ days
● Also proliferative endometrium and secretory stroma

Pathophysiology
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● Often due to dysfunctional uterine bleeding (DUB)
● DUB patients lack cyclic endometrial stimulation; instead have constant unopposed estrogen production with continuous endometrial stimulation; endometrium outgrows its blood supply, leading to tissue breakdown and sloughing
● Healing of this endometrium is irregular and dyssynchronous (eMedicine)

Micro images
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Dyssynchronous endometrium

End of Uterus > Non tumor > Dyssynchronous endometrium


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