Dyssynchronous endometrium

Topic Completed: 1 December 2011

Revised: 21 February 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed search: dyssynchronous endometrium

Nat Pernick, M.D.
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Cite this page: Pernick N. Dyssynchronous endometrium. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusdyssynchronous.html. Accessed August 24th, 2019.
Definition / general
  • Discordance between glands and stroma, both usually in secretory phasel
  • Also defined as endometrial glandular dating lagging both chronological and stromal dating by 3+ days
  • Also proliferative endometrium and secretory stroma
  • Often due to dysfunctional uterine bleeding (DUB)
  • DUB patients lack cyclic endometrial stimulation; instead have constant unopposed estrogen production with continuous endometrial stimulation; endometrium outgrows its blood supply, leading to tissue breakdown and sloughing
  • Healing of this endometrium is irregular and dyssynchronous (eMedicine)
Microscopic (histologic) images

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Dyssynchronous endometrium

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