Endometrial curettage and biopsy
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 3 October 2011, last major update October 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● D&C (dilatation and curettage, Wikipedia) and endometrial biopsy (Wikipedia, video) are methods of choice for sampling localized lesions; D&C undergrades the FIGO grade in well differentiated adenocarcinomas in 9% of cases compared to 18% for endometrial biopsy
(Gynecol Oncol 2009;113:105)
● Fractional curettage: separate sampling from endometrial and endocervical cavities during same procedure; do endocervix first to minimize contamination
● Note: report endocervical extension of a tumor only if normal endocervical glands and carcinoma are present in the SAME fragment
● Ashermanís syndrome: intrauterine adhesions after D & C, causing amenorrhea; usually postpartum or post-termination, may be due to subclinical uterine infection (Wikipedia)
● Endometrial biopsy: to evaluate infertile or dysmenorrheic patients; sensitive if done properly; may contain mesothelial cells, which can cause confusion (Am J Surg Pathol 2010;34:124)
● Helpful clinical information: patientís age, date and characteristics of last and current menstrual period, use of hormones/steroids, chief complaint and physical findings
End of Uterus > Non tumor > Endometrial curettage and biopsy
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