Non tumor
Endometrial curettage and biopsy

Author: Nat Pernick, M.D. (see Authors page)

Revised: 12 January 2017, last major update October 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: endometrial curettage biopsy uterus

Table of Contents
Definition / general
Cite this page: Endometrial curettage and biopsy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusendobiopsy.html. Accessed October 17th, 2018.
Definition / general
  • D&C (dilatation and curettage, Wikipedia) and endometrial biopsy (Wikipedia) are methods of choice for sampling localized lesions; D&C undergrades the FIGO grade in well differentiated adenocarcinomas in 9% of cases compared to 18% for endometrial biopsy (Gynecol Oncol 2009;113:105)
  • Fractional curettage: separate sampling from endometrial and endocervical cavities during same procedure; do endocervix first to minimize contamination
  • Note: report endocervical extension of a tumor only if normal endocervical glands and carcinoma are present in the SAME fragment
  • Asherman's syndrome: intrauterine adhesions after D & C, causing amenorrhea; usually postpartum or post termination, may be due to subclinical uterine infection (Wikipedia)
  • Endometrial biopsy: to evaluate infertile or dysmenorrheic patients; sensitive if done properly; may contain mesothelial cells, which can cause confusion (Am J Surg Pathol 2010;34:124)
  • Helpful clinical information: patient's age, date and characteristics of last and current menstrual period, use of hormones / steroids, chief complaint and physical findings