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Endometrial curettage and biopsy

Topic Completed: 1 October 2011

Revised: 20 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed search: endometrial curettage biopsy uterus

Nat Pernick, M.D.
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Page views in 2019 to date: 2,140
Table of Contents
Definition / general
Cite this page: Pernick N. Endometrial curettage and biopsy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusendobiopsy.html. Accessed August 24th, 2019.
Definition / general
  • D&C (dilatation and curettage, Wikipedia) and endometrial biopsy (Wikipedia) are methods of choice for sampling localized lesions; D&C undergrades the FIGO grade in well differentiated adenocarcinomas in 9% of cases compared to 18% for endometrial biopsy (Gynecol Oncol 2009;113:105)
  • Fractional curettage: separate sampling from endometrial and endocervical cavities during same procedure; do endocervix first to minimize contamination
  • Note: report endocervical extension of a tumor only if normal endocervical glands and carcinoma are present in the SAME fragment
  • Asherman's syndrome: intrauterine adhesions after D & C, causing amenorrhea; usually postpartum or post termination, may be due to subclinical uterine infection (Wikipedia)
  • Endometrial biopsy: to evaluate infertile or dysmenorrheic patients; sensitive if done properly; may contain mesothelial cells, which can cause confusion (Am J Surg Pathol 2010;34:124)
  • Helpful clinical information: patient's age, date and characteristics of last and current menstrual period, use of hormones / steroids, chief complaint and physical findings
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