Uterus
Nontumor
Chronic endometritis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 May 2018, last major update November 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed search: Chronic [title] endometritis

Related topics: Endometritis

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Cite this page: Pernick, N. Chronic endometritis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusendometritischronic.html. Accessed July 18th, 2019.
Clinical features
  • In women with pelvic inflammatory disease (PID), postpartum, postabortion (retained tissue), IUD, tuberculosis (miliary or TB salpingitis) and symptomatic bacterial vaginosis
  • 15% have unknown cause (may be chlamydia, give antibiotics)
  • Often asymptomatic (Am J Reprod Immunol 2011;66:410)
Microscopic (histologic) description
  • Spindly stroma with edema; focal early breakdown with surface neutrophils
  • Associated with weakly proliferative glands
  • Plasma cells are characteristic but one plasma cell is probably not enough; usually histiocytes, lymphocytes and lymphoid follicles are also present; glandular alterations usually make dating impossible
  • Also focal necrosis or focal calcification; myometrium usually spared unless inflammation is severe
  • Presence of eosinophils may suggest need to search for plasma cells, with CD138 if necessary (Hum Pathol 2010;41:33)
  • Note: lymphoid follicles are normal in functional layers of endometrial mucosa and do not constitute chronic endometritis
  • Note: plasma cells may occasionally be seen in nonendometritis cases (Pathol Res Pract 2011;207:680), including dysfunctional uterine bleeding and stromal breakdown (Hum Pathol 2007;38:581)
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Yuri Tachibana, M.D., Nagasaki University:

Plasma cells

CD138



AFIP images:

Chronic endometritis with reactive glandular proliferation:
the spindled stroma contains a massive lymphoplasmacytic
infiltrate; endometrial glands are irregularly distributed and variable
in size and shape but are also infiltrated by the inflammatory cells



Images hosted on other servers:

Chronic endometritis (various images)


CD138 (syndecan) staining

Tuberculous endometritis


Xanthogranulomatous endometritis (various images)

Positive stains
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