Endometrial carcinoma
Giant cell carcinoma

Topic Completed: 1 September 2011

Revised: 25 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed search: giant cell carcinoma uterus

Nat Pernick, M.D.
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Cite this page: Pernick N. Giant cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusgiantcell.html. Accessed August 25th, 2019.
Definition / general
  • High grade endometrial adenocarcinomas with a malignant giant cell component and aggressive clinical course (Int J Gynecol Pathol 1991;10:260)
  • Recent case series (Am J Surg Pathol 2010;34:1132), but overall very few cases reported
  • Rare, high grade tumor with poorly cohesive sheets and nests of bizarre, pleomorphic and multinucleated giant cells and mononuclear tumor cells
  • In contrast to osteoclast-like giant cell tumors, giant cells are clustered, and not evenly distributed
  • Usually coexists with endometrial adenocarcinoma
  • Also peritumoral and intratumoral inflammatory cell infiltrate of lymphocytes, plasma cells, eosinophils and neutrophils with emperipolesis
Case reports
Microscopic (histologic) images

Images hosted on PathOut server:

A single gland is present in this field,
but most of the tumor grows as
solid sheets of anaplastic cells,
many of which are multinucleate

Positive stains
Differential diagnosis
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