Uterus
Endometrial carcinoma
Giant cell carcinoma



Topic Completed: 1 September 2011

Revised: 25 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed search: giant cell carcinoma uterus

Nat Pernick, M.D.
Page views in 2018: 489
Page views in 2019 to date: 243
Cite this page: Pernick N. Giant cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusgiantcell.html. Accessed June 24th, 2019.
Definition / general
  • High grade endometrial adenocarcinomas with a malignant giant cell component and aggressive clinical course (Int J Gynecol Pathol 1991;10:260)
  • Recent case series (Am J Surg Pathol 2010;34:1132), but overall very few cases reported
  • Rare, high grade tumor with poorly cohesive sheets and nests of bizarre, pleomorphic and multinucleated giant cells and mononuclear tumor cells
  • In contrast to osteoclast-like giant cell tumors, giant cells are clustered, and not evenly distributed
  • Usually coexists with endometrial adenocarcinoma
  • Also peritumoral and intratumoral inflammatory cell infiltrate of lymphocytes, plasma cells, eosinophils and neutrophils with emperipolesis
Case reports
Microscopic (histologic) images

Images hosted on PathOut server:

A single gland is present in this field,
but most of the tumor grows as
solid sheets of anaplastic cells,
many of which are multinucleate

Positive stains
Differential diagnosis
Back to top