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Endometrial carcinoma

Giant cell carcinoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 September 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● High grade endometrial adenocarcinomas with a malignant giant cell component and aggressive clinical course (Int J Gynecol Pathol 1991;10:260)
● Recent case series (Am J Surg Pathol 2010;34:1132), but overall very few cases reported


● Rare, high grade tumor with poorly cohesive sheets and nests of bizarre, pleomorphic and multinucleated giant cells and mononuclear tumor cells
● In contrast to osteoclast-like giant cell tumors, giant cells are clustered, and not evenly distributed
● Usually coexists with endometrial adenocarcinoma
● Also peritumoral and intratumoral inflammatory cell infiltrate of lymphocytes, plasma cells, eosinophils and neutrophils with emperipolesis

Case reports

● 70 year old woman with postmenopausal bleeding (Internet Journal of Gynecology and Obstetrics 2009;12(1))

Micro images

Sheets of pleomorphic giant cells

A single gland is present in this field, but most of the tumor grows as solid sheets of anaplastic cells, many of which are multinucleate

Positive stains

● Giant cells: focal staining for AE1/AE3 and CAM 5.2

Differential diagnosis

● Tumors with osteoclast-like giant cells resembling giant cell tumor of bone: giant cells and mononuclear cells are evenly distributed, not clustered (APMIS 2005;113:140, BMC Cancer 2007 Mar 14;7:46)

End of Uterus > Endometrial carcinoma > Giant cell carcinoma

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