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Uterus
Endometrial carcinoma
Glassy cell carcinoma
Copyright: 2002-2017, PathologyOutlines.com, Inc.
PubMed search: glassy cell carcinoma
Endometrial carcinoma
Glassy cell carcinoma
Author: Nat Pernick, M.D.
Topic Completed: 1 September 2011
Revised: 25 February 2019
Copyright: 2002-2017, PathologyOutlines.com, Inc.
PubMed search: glassy cell carcinoma
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Positive stains | Electron microscopy descriptionCite this page: Pernick N. Glassy cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusglassycell.html. Accessed August 24th, 2019.
Definition / general
- Rare type of adenosquamous carcinoma, similar to cervical counterpart
- See also topic in Cervix chapter
Case reports
- 60 year old woman (Arch Pathol Lab Med 2001;125:816)
- 63 year old woman (Pathol Res Pract 2007;203:217)
- 68 year old woman (Orv Hetil 2009;150:1173)
Microscopic (histologic) description
- Diffuse solid sheets of tumor cells with eosinophilic, ground glass cytoplasm, distinct cell walls, large nuclei and prominent nucleoli
- Frequent mitotic figures
- Heavy eosinophilic and lymphocytic infiltrate common
- Usually some glandular component
- Most authors require 30% - 100% of glassy cells for diagnosis
Microscopic (histologic) images
Images hosted on other servers:
Various images
Various images - cervix
Positive stains
- p63 (67%), mucin or CEA (56%), HPV (67%, Int J Gynecol Pathol 2009;28:389)
Electron microscopy description
- Intermediate filaments, polyribosomes, tonofibrils and desmosomes
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