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Uterus

Endometrial carcinoma

Glassy cell carcinoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 September 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

See also topic in Cervix chapter

Definition
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● Rare type of adenosquamous carcinoma, similar to cervical counterpart

Case reports
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● 60 year old woman (Arch Pathol Lab Med 2001;125:816)
● 63 year old woman (Pathol Res Pract 2007;203:217)
● 68 year old woman (Orv Hetil 2009;150:1173)

Micro description
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● Diffuse solid sheets of tumor cells with eosinophilic, ground-glass cytoplasm, distinct cell walls, large nuclei and prominent nucleoli
● Frequent mitotic figures
● Heavy eosinophilic and lymphocytic infiltrate common
● Usually some glandular component
● Most authors require 30%-100% of glassy cells for diagnosis

Micro images
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Various images

   
Various images-cervix

Positive stains
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● p63 (67%), mucin or CEA (56%), HPV (67%, Int J Gynecol Pathol 2009;28:389)

EM description
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● Intermediate filaments, polyribosomes, tonofibrils and desmosomes

Positive stains
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● Variable keratin, EMA and CEA

End of Uterus > Endometrial carcinoma > Glassy cell carcinoma

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