Glassy cell carcinoma
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 September 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
See also topic in Cervix chapter
● Rare type of adenosquamous carcinoma, similar to cervical counterpart
● 60 year old woman (Arch Pathol Lab Med 2001;125:816)
● 63 year old woman (Pathol Res Pract 2007;203:217)
● 68 year old woman (Orv Hetil 2009;150:1173)
● Diffuse solid sheets of tumor cells with eosinophilic, ground-glass cytoplasm, distinct cell walls, large nuclei and prominent nucleoli
● Frequent mitotic figures
● Heavy eosinophilic and lymphocytic infiltrate common
● Usually some glandular component
● Most authors require 30%-100% of glassy cells for diagnosis
● p63 (67%), mucin or CEA (56%), HPV (67%, Int J Gynecol Pathol 2009;28:389)
● Intermediate filaments, polyribosomes, tonofibrils and desmosomes
● Variable keratin, EMA and CEA
End of Uterus > Endometrial carcinoma > Glassy cell carcinoma
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