Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Uterus (excludes Cervix)

Stromal tumors

Inflammatory pseudotumor

Reviewer: Mohamed Mokhtar Desouki, MD, PhD (see Reviewers page)
Revised: 15 March 2012, last major update August 2011
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
=========================================================================

● The term "inflammatory pseudotumor" is applied to a variety of neoplastic and non-neoplastic entities, characterized by a collection of lymphocytes, plasma cells and neutrophils forming a well circubscribed mass
● Also includes inflammatory myoblastic tumors with distinct clinical, pathological and molecular features

Terminology
=========================================================================

● Inflammatory pseudotumor (IPT), inflammatory myoblastic tumor (IMT)

Epidemiology
=========================================================================

● Younger age than other uterine tumors

Sites
=========================================================================

● All locations

Etiology
=========================================================================

● May be preceded by an acute infection and represent an immunologic reparative response or a low-grade spindle cell fibrosarcoma

Clinical features
=========================================================================

● May present with unexplained fever, abdominal pain, anorexia and weight loss
● On pelvic examination, the uterus may be bulky and tender with restricted mobility giving the impression of "frozen pelvis"
● Laboratory findings: elevated ESR and serum immunoglobulins, thrombocytosis and anemia

Prognostic factors
=========================================================================

● IPTs may recur locally but do not metastasize
● IMTs have intermediate biological potential for local recurrence and distant metastasis
● Mortality rate of 7%

Treatment
=========================================================================

● Surgical excision is curative in 90% of cases
● Antibiotic therapy may be useful

Gross description
=========================================================================

● Circumscribed mass

Micro description
=========================================================================

● Mixture of spindle cells exhibiting storiform pattern together with numerous lymphocytes, plasma cells and histiocytes
● In part, a diagnosis of exclusion

Cytology description
=========================================================================

● Fine needle aspiration may demonstrate inflammatory epitheloid granuloma

Positive stains
=========================================================================

● Vimentin and IL-6

Negative stains
=========================================================================

● Desmin, alpha smooth muscle actin, CD68, lysozyme

Differential Diagnosis
=========================================================================

● Genital tuberculosis
● Inflammatory sarcomatoid carcinomas
● Endometrial stromal sarcoma
● Cellular or inflammatory leiomyoma
● Myometritis

Additional references
=========================================================================

● Eur J Obstet Gynecol Reprod Biol 2011;156:118

End of Uterus > Stromal tumors > Inflammatory pseudotumor

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).