Uterus
Stromal tumors
Inflammatory myofibroblastic tumor

Author: Mohamed Mokhtar Desouki, M.D., Ph.D. (see Authors page)

Revised: 5 March 2017, last major update August 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: uterus "inflammatory myofibroblastic tumor"

Cite this page: Inflammatory myofibroblastic tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusinflammpseudo.html. Accessed July 27th, 2017.
Definition / general
  • The term "inflammatory pseudotumor" is applied to a variety of neoplastic and nonneoplastic entities, characterized by a collection of lymphocytes, plasma cells and neutrophils forming a well circumscribed mass
  • Also includes inflammatory myoblastic tumors with distinct clinical, pathological and molecular features, which is now the preferred terminology
Terminology
  • Inflammatory pseudotumor (IPT), inflammatory myoblastic tumor (IMT)
Epidemiology
  • Younger age than other uterine tumors
Sites
  • All locations
Etiology
  • May be preceded by an acute infection and represent an immunologic reparative response or a low grade spindle cell fibrosarcoma
Clinical features
  • May present with unexplained fever, abdominal pain, anorexia and weight loss
  • On pelvic examination, the uterus may be bulky and tender with restricted mobility giving the impression of "frozen pelvis"
  • Laboratory findings: elevated ESR and serum immunoglobulins, thrombocytosis and anemia
Prognostic factors
  • IPTs may recur locally but do not metastasize
  • IMTs have intermediate biological potential for local recurrence and distant metastasis
  • Mortality rate of 7%
Treatment
  • Surgical excision is curative in 90% of cases
  • Antibiotic therapy may be useful
Gross description
  • Circumscribed mass
Microscopic (histologic) description
  • Mixture of spindle cells exhibiting storiform pattern together with numerous lymphocytes, plasma cells and histiocytes
  • In part, a diagnosis of exclusion
Cytology description
  • Fine needle aspiration may demonstrate inflammatory epitheloid granuloma
Positive stains
Differential diagnosis