Stromal tumors
Disseminated peritoneal leiomyomatosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 February 2017, last major update August 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: disseminated peritoneal leiomyomatosis uterus

Related topics: leiomyoma

Cite this page: Disseminated peritoneal leiomyomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusleiomyomadisseminated.html. Accessed May 27th, 2018.
Definition / general
  • Rare, benign but pseudomalignant lesion of multiple peritoneal nodules < 2 cm that cover peritoneal surface, and clinically mimics disseminated abdominal carcinoma (Am J Surg Pathol 1980;4:197)
  • Also called leiomyomatosis peritonealis disseminata
  • Usually young women, associated with pregnancy (discovered at caesarean section), other altered hormonal conditions, endometriosis (Arch Pathol Lab Med 1984;108:669) or laparoscopic supracervical hysterectomy with morcellation for uterine leiomyomata (Genes Chromosomes Cancer 2010;49:1152)
  • Nodules almost always regress spontaneously, but systemic chemotherapy has been suggested as a treatment option for rare cases of unresectable or metastatic tumors (Orphanet)
  • Should rule out GI or retroperitoneal masses (GIST, leiomyosarcoma) before making this diagnosis
  • Nodules are composed of fibroblasts and bland smooth muscle cells; decidual cells common
Clinical images

Images hosted on other servers:

Pelvic masses at laparoscopy

Intraoperative ap-
pearance of nodules
scattered over
the peritoneum

Numerous leiomyomas
extending along the
peritoneum (fig 1g)

Gross images

Images hosted on other servers:

36 year old woman with intraperitoneal soft-tissue nodules (fig 5c, d)

Microscopic (histologic) images

Images hosted on other servers:

Various images

Molecular / cytogenetics description