Uterus
Stromal tumors
Mitotically active leiomyoma


Topic Completed: 1 August 2011

Minor changes: 15 December 2019

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PubMed search: mitotically active leiomyoma

Related topics: leiomyoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Mitotically active leiomyoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusleiomyomamitotic.html. Accessed May 24th, 2020.
Definition / general
  • Usually young patients; often submucous leiomyomas with extensive necrosis that protrude into endometrial cavity
  • Grossly and microscopically typical for leiomyomas, but 5 - 15 mitoses per 10 HPF (Am J Clin Pathol 1992;97:14)
  • NO moderate / severe nuclear atypia, NO abnormal mitotic figures and NO tumor cell necrosis
  • Typically benign behavior, but recurrence as leiomyosarcoma has been reported (J Obstet Gynaecol Res 2010;36:187)
  • Case reports: 56 year old woman taking tamoxifen for breast cancer (Taiwan J Obstet Gynecol 2006;45:167)
  • Treatment: myomectomy is usually adequate (Hum Pathol 1990;21:223)
Microscopic (histologic) images

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Mitotically active leiomyoma of uterus

Differential diagnosis
  • Leiomyosarcoma: usually marked atypia, coagulative cell necrosis, infiltrative
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