Smooth muscle tumors
Leiomyoma with bizarre nuclei

Topic Completed: 9 February 2017

Minor changes: 21 October 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed search: symplastic [title] OR atypical [title] leiomyoma

Related topics: leiomyoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Leiomyoma with bizarre nuclei. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusleiomyomasymplastic.html. Accessed August 6th, 2020.
Definition / general
  • Contains bizarre multinucleated tumor cells (moderate / severe atypia), less than 10 mitotic figures/10 HPF and NO tumor cell necrosis
  • Associated with progestin use
  • Benign behavior (Am J Surg Pathol 1997;21:1261), but rarely leiomyosarcomas may arise from them (Mod Pathol 2009;22:1303)
  • Previously called symplastic or atypical leiomyoma
Case reports
Gross images

Images hosted on other servers:

Bizarre leiomyoma

Microscopic (histologic) images

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Case of the Week #352:

Various images

Various images

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Atypical leiomyoma:

Various images

Positive stains
Additional references
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