Non tumor
Luteal phase defect

Topic Completed: 1 September 2011

Revised: 21 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed search: luteal phase defect uterus

Nat Pernick, M.D.
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Cite this page: Pernick N. Luteal phase defect. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uteruslutealphase.html. Accessed August 23rd, 2019.
Definition / general
  • Due to inadequate progesterone production (Wikipedia)
  • Historically was thought to be associated with infertility and spontaneous abortions, but now questioned (Obstet Gynecol Clin North Am 2004;31:727)
  • Lag of histologic endometrial date of 3+ days from actual postovulatory date (some say 2+ days)
  • Must be found in 2 consecutive cycles to be clinically significant
  • Relevance of this concept has been questioned (Hum Fertil (Camb) 2011;14:60)
  • Clomiphene citrate or human menopausal gonadotropins (hMG) to stimulate follicular growth; supplemental hCG to improve corpus luteum secretion of progesterone; additional progesterone after ovulation
Microscopic (histologic) description
  • Either immature endometrium or persistence of proliferative changes
  • May see dyssynchronous endometrium (dissociation between endometrial glands and stroma)
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