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Non tumor

Luteal phase defect

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 3 October 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Due to inadequate progesterone production (Wikipedia)
● Historically was thought to be associated with infertility and spontaneous abortions, but now questioned (Obstet Gynecol Clin North Am 2004;31:727)
● Lag of histologic endometrial date of 3+ days from actual post-ovulatory date (some say 2+ days)
● Must be found in 2 consecutive cycles to be clinically significant
● Relevance of this concept has been questioned (Hum Fertil (Camb) 2011;14:60)


● Clomiphene citrate or human menopausal gonadotropins (hMG) to stimulate follicular growth; supplemental hCG to improve corpus luteum secretion of progesterone; additional progesterone after ovulation

Micro description

● Either immature endometrium or persistence of proliferative changes
● May see dyssynchronous endometrium (dissociation between endometrial glands and stroma)

End of Uterus > Non tumor > Luteal phase defect

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