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Other tumors

Melanoma of uterus

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 September 2011, last major update October 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Very rare, either as primary or metastatic tumor
● Uterine metastases may derive from primaries in skin (Gynecol Oncol 2004;93:252), uvea (Pathol Oncol Res 2006;12:184) or hard palate (Can J Surg 2002;45:461)
● Melanoma may metastasize to uterine polyps, including adenomyomas (Int J Surg Pathol 2005;13:223)
● Some uterine melanomas may originate in cervix, see Cervix chapter
● Poor prognosis in uterus or cervix, whether tumor is primary or secondary
● Primary uterine tumors may arise from lentigo or blue nevus (Diagn Gynecol Obstet 1981;3:269)

Case reports

● 58 year old woman with post-menopausal bleeding (Case of the Week #109)

Micro images

Case of Week #109

Left to right: MART1, HMB45, S100

Left to right: CAM5.2, CK7, CK20

Tumor with prominent nucleoli and pigment

End of Uterus > Other tumors > Melanoma of uterus

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