Uterus - Oxyphilic cell carcinoma

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Uterus (excludes Cervix)

Epithelial tumors

Oxyphilic cell carcinoma

Reviewer: Mohamed Mokhtar Desouki, MD, PhD (see Reviewers page)
Revised: 22 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Endometrioid carcinoma composed predominantly of cells with abundant oxyphilic eosinophilic cytoplasm

Terminology
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● Also called oncocytic carcinoma

Epidemiology
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● Rare tumors affecting younger patients age 37 to 50 years (mean of 44 years)

Etiology
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● Unknown

Clinical features
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● Similar clinical presentation and behavior as typical endometrioid carcinoma (Int J Gynecol Pathol 1994;13:290)

Prognostic factors
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● Grade 1 or 2 with favorable prognosis, although solid nests of cells with eosinophilic cytoplasm are described in high-grade carcinomas

Treatment
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● Similar to conventional endometrioid adenocarcinoma - total abdominal hysterectomy with pre- and postoperative radiation

Gross description
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● Similar to other variants of endometrioid adenocarcinoma; may not be apparent on gross examination
● May resemble thickened late secretory phase endometrium
● Visible tumors vary from sessile polyps to nodules or irregular, thickened plaques that may be localized or diffuse

Micro description
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● Confluent glandular or solid growth pattern of oxyphilic cells lining glands with or without prominent luminal and intracytoplasmic mucin
● Carcinomas resemble metaplasia but with occasional nuclear stratification, greater pleomorphism and mitotic figures

Positive stains
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● p53

Negative stains
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● ER (75%), PR (100%)

EM description
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● Abundant mitochondria and free ribosomes

Differential Diagnosis
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● Eosinophilic metaplasia: no atypia, no mitotic figures

Additional references
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● Adv Anat Pathol 2002;9:145

End of Uterus > Epithelial tumors > Oxyphilic cell carcinoma

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