Oxyphilic cell carcinoma

Author: Mohamed Mokhtar Desouki, M.D., Ph.D. (see Authors page)

Revised: 25 January 2017, last major update August 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: uterine oxyphilic cell carcinoma

Cite this page: Oxyphilic cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusoxyphilic.html. Accessed November 21st, 2018.
Definition / general
  • Endometrioid carcinoma composed predominantly of cells with abundant oxyphilic eosinophilic cytoplasm
  • Also called oncocytic carcinoma
  • Rare tumors affecting younger patients age 37 to 50 years (mean of 44 years)
  • Unknown
Clinical features
Prognostic factors
  • Grade 1 or 2 with favorable prognosis, although solid nests of cells with eosinophilic cytoplasm are described in high grade carcinomas
  • TAH / BSO then possible radiation (for advanced disease) for disease limited to the uterus (NCCN Guidelines Version 1.2014); consideration of preoperative radiation for tumors grossly involving the cervix before doing surgery (this is uncommon)
Gross description
  • Similar to other variants of endometrioid adenocarcinoma; may not be apparent on gross examination
  • May resemble thickened late secretory phase endometrium
  • Visible tumors vary from sessile polyps to nodules or irregular, thickened plaques that may be localized or diffuse
Microscopic (histologic) description
  • Confluent glandular or solid growth pattern of oxyphilic cells lining glands with or without prominent luminal and intracytoplasmic mucin
  • Carcinomas resemble metaplasia but with occasional nuclear stratification, greater pleomorphism and mitotic figures
Positive stains
Negative stains
  • ER (75%), PR (100%)
Electron microscopy description
  • Abundant mitochondria and free ribosomes
Differential diagnosis
  • Eosinophilic metaplasia: no atypia, no mitotic figures
Additional references