Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Uterus

Stromal tumors

Plexiform tumor / tumorlet


Reviewer: Mohamed Desouki, M.D. (see Reviewers page)
Revised: 27 September 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
=========================================================================

● Benign neoplasms related to endometrial stroma closely related to uterine tumors resembling ovarian sex-cord tumors
● Note: tumor not included in the World Health Organization tumor classification

Terminology
=========================================================================

● Endometrial glomus tumour, solid angioma

Epidemiology
=========================================================================

● Very rare tumors with an average age of 48-60 years

Etiology
=========================================================================

● Unknown

Clinical features
=========================================================================

● Incidental finding

Prognostic factors
=========================================================================

● Mostly behaves in benign fashion

Gross description
=========================================================================

● Minute neoplasms usually 1 cm or less, but may be large or multiple
● Nodular and well circumscribed or may exhibit irregular borders

Micro description
=========================================================================

● Cells with crumbled nuclei, indistinct cytoplasm arranged in cords or rows in branching pattern separated by hyalinized stroma
● The cells may merge with foam cells similar to luteinized ovarian stromal cells
● Mitotic activity is sparse
● Tumors usually identified at endomyometrial junction
● Also reported in adenomyosis and in endometrial polyp

Positive stains
=========================================================================

● Coexpresses myoid, epithelial and sex cord markers
● Smooth muscle actin and desmin, CD56, CAM5.2 (focally positive), ER, PR (Histopathology 2009;54:497)

Negative stains
=========================================================================

● Vimentin, alpha-Inhibin, calretinin, cytokeratin 7, EMA

EM description
=========================================================================

● Appears to have smooth muscle origin by EM

End of Uterus > Stromal tumors > Plexiform tumor / tumorlet


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).