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Table of Contents
Definition / general | Terminology | Epidemiology | Etiology | Clinical features | Prognostic factors | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Electron microscopy descriptionCite this page: Plexiform tumor / tumorlet. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusplexiformtumor.html. Accessed July 16th, 2017.
Definition / general
- Benign neoplasms related to endometrial stroma closely related to uterine tumors resembling ovarian sex cord tumors
- Note: tumor not included in the World Health Organization tumor classification
Terminology
- Endometrial glomus tumour, solid angioma
Epidemiology
- Very rare tumors with an average age of 48 - 60 years
Etiology
- Unknown
Clinical features
- Incidental finding
Prognostic factors
- Mostly behaves in benign fashion
Gross description
- Minute neoplasms usually 1 cm or less, but may be large or multiple
- Nodular and well circumscribed or may exhibit irregular borders
Microscopic (histologic) description
- Cells with crumbled nuclei, indistinct cytoplasm arranged in cords or rows in branching pattern separated by hyalinized stroma
- The cells may merge with foam cells similar to luteinized ovarian stromal cells
- Mitotic activity is sparse
- Tumors usually identified at endomyometrial junction
- Also reported in adenomyosis and in endometrial polyp
Positive stains
- Coexpresses myoid, epithelial and sex cord markers
- Smooth muscle actin and desmin, CD56, CAM 5.2 (focally positive), ER, PR (Histopathology 2009;54:497)
Negative stains
Electron microscopy description
- Appears to have smooth muscle origin by EM
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