Uterus - Plexiform tumor / tumorlet

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Uterus

Stromal tumors

Plexiform tumor / tumorlet

Reviewer: Mohamed Desouki, M.D. (see Reviewers page)
Revised: 27 September 2011, last major update September 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Benign neoplasms related to endometrial stroma closely related to uterine tumors resembling ovarian sex-cord tumors
● Note: tumor not included in the World Health Organization tumor classification

Terminology
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● Endometrial glomus tumour, solid angioma

Epidemiology
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● Very rare tumors with an average age of 48-60 years

Etiology
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● Unknown

Clinical features
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● Incidental finding

Prognostic factors
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● Mostly behaves in benign fashion

Gross description
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● Minute neoplasms usually 1 cm or less, but may be large or multiple
● Nodular and well circumscribed or may exhibit irregular borders

Micro description
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● Cells with crumbled nuclei, indistinct cytoplasm arranged in cords or rows in branching pattern separated by hyalinized stroma
● The cells may merge with foam cells similar to luteinized ovarian stromal cells
● Mitotic activity is sparse
● Tumors usually identified at endomyometrial junction
● Also reported in adenomyosis and in endometrial polyp

Positive stains
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● Coexpresses myoid, epithelial and sex cord markers
● Smooth muscle actin and desmin, CD56, CAM5.2 (focally positive), ER, PR (Histopathology 2009;54:497)

Negative stains
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● Vimentin, alpha-Inhibin, calretinin, cytokeratin 7, EMA

EM description
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● Appears to have smooth muscle origin by EM

End of Uterus > Stromal tumors > Plexiform tumor / tumorlet

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