Stromal tumors
Plexiform tumor / tumorlet

Topic Completed: 1 September 2011

Revised: 25 February 2019

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PubMed search: plexiform tumor uterus

Mohamed Mokhtar Desouki, M.D., Ph.D.
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Cite this page: Desouki M. Plexiform tumor / tumorlet. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusplexiformtumor.html. Accessed September 22nd, 2019.
Definition / general
  • Benign neoplasms related to endometrial stroma closely related to uterine tumors resembling ovarian sex cord tumors
  • Note: tumor not included in the World Health Organization tumor classification
  • Endometrial glomus tumour, solid angioma
  • Very rare tumors with an average age of 48 - 60 years
  • Unknown
Clinical features
  • Incidental finding
Prognostic factors
  • Mostly behaves in benign fashion
Gross description
  • Minute neoplasms usually 1 cm or less, but may be large or multiple
  • Nodular and well circumscribed or may exhibit irregular borders
Microscopic (histologic) description
  • Cells with crumbled nuclei, indistinct cytoplasm arranged in cords or rows in branching pattern separated by hyalinized stroma
  • The cells may merge with foam cells similar to luteinized ovarian stromal cells
  • Mitotic activity is sparse
  • Tumors usually identified at endomyometrial junction
  • Also reported in adenomyosis and in endometrial polyp
Positive stains
Electron microscopy description
  • Appears to have smooth muscle origin by EM
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