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Table of Contents
Definition / general | Terminology | Sites | Etiology | Clinical features | Prognostic factors | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Negative stains | Differential diagnosisCite this page: Postoperative spindle cell tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uteruspostop.html. Accessed July 16th, 2017.
Definition / general
- Similar to spindle cell nodule elswhere, e.g. vagina, urinary bladder, endocervix and other sites (Am J Surg Pathol 1984;8:101)
Terminology
- Postoperative spindle cell nodule
Sites
- Post procedural, e.g. dilatation and curettage
Etiology
- Reparative proliferations of fibroblastic cells in response to an inciting factor
Clinical features
- Vaginal bleeding
Prognostic factors
- No recurrence reported even after incomplete excision
Case reports
- 75 year old woman post D&C (Arch Pathol Lab Med 1988;112:566)
Microscopic (histologic) description
- Dense cellular proliferation of mitotically active spindle cells which have elongated nuclei with evenly dispersed chromatin and abundant eosinophilic cytoplasm
- Marked vascularity with extravasated RBCs and hemosiderin
- Mitotic rate is often high, but abnormal mitoses or atypia are absent
Microscopic (histologic) images
Images hosted on other servers:
Bladder tumor
Negative stains
Differential diagnosis
- Sarcoma NOS: Marked nuclear anaplasia, variable pleomorphism, 20+ mitotic figures/10 HPF; extensive necrosis is common
- Sarcomatoid carcinoma / MMMT: biphasic with sarcomatoid and carcinomatous elements; angiolymphatic invasion common; keratin+
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