Uterus - Malignant extrarenal rhabdoid tumor

Home Chapter Home Jobs Conferences Fellowships Books

Uterus

Other tumors

Malignant extrarenal rhabdoid tumor

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 March 2012, last major update March 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Highly aggressive tumors in adults; rapidly fatal
● First reported in uterus in 1989 (Int J Gynecol Pathol 1989;8:381)

Case reports
=========================================================================

● 49 year old woman with collision of uterine rhabdoid tumor and endometrioid adenocarcinoma (Int J Gynecol Pathol 1999;18:396)
● 71 year old woman with post-menopausal bleeding (Hum Pathol 2001;32:884)

Micro description
=========================================================================

● Solid sheets of large cells with deep eosinophilic cytoplasm, eosinophilic hyaline cytoplasmic inclusions; eccentric vesicular nuclei, prominent nucleoli

Micro images
=========================================================================

Rhabdoid tumor

Rhabdoid cells

Fig B: rhabdoid tumor component

Positive stains
=========================================================================

● Cytoplasmic staining for vimentin, desmin, CAM 5.2

Negative stains
=========================================================================

● Loss of INI1 expression (Stains chapter)
● CEA, EMA

Electron microscopy description
=========================================================================

● Paranuclear arrays of intermediate filaments

Cytogenetic description
=========================================================================

● Translocations of 22q11-12 in many cases

Differential diagnosis
=========================================================================

● Endometrial stromal sarcoma with rhabdoid features: stromal component (Histopathology 1996;29:369)
● Leiomyosarcoma with rhabdoid features: smooth muscle component (Wien Klin Wochenschr 2007;119:557, Int J Surg Pathol 2002;10:231)

End of Uterus > Other tumors > Malignant extrarenal rhabdoid tumor

Ref Updated: 3/5/12

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).