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Uterus

Other tumors

Malignant extrarenal rhabdoid tumor


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 March 2012, last major update March 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Highly aggressive tumors in adults; rapidly fatal
● First reported in uterus in 1989 (Int J Gynecol Pathol 1989;8:381)

Case reports
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● 49 year old woman with collision of uterine rhabdoid tumor and endometrioid adenocarcinoma (Int J Gynecol Pathol 1999;18:396)
● 71 year old woman with post-menopausal bleeding (Hum Pathol 2001;32:884)

Micro description
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● Solid sheets of large cells with deep eosinophilic cytoplasm, eosinophilic hyaline cytoplasmic inclusions; eccentric vesicular nuclei, prominent nucleoli

Micro images
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Rhabdoid tumor


Rhabdoid cells


Fig B: rhabdoid tumor component

Positive stains
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● Cytoplasmic staining for vimentin, desmin, CAM 5.2

Negative stains
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● Loss of INI1 expression (Stains chapter)
● CEA, EMA

Electron microscopy description
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● Paranuclear arrays of intermediate filaments

Cytogenetic description
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● Translocations of 22q11-12 in many cases

Differential diagnosis
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Endometrial stromal sarcoma with rhabdoid features: stromal component (Histopathology 1996;29:369)
Leiomyosarcoma with rhabdoid features: smooth muscle component (Wien Klin Wochenschr 2007;119:557, Int J Surg Pathol 2002;10:231)

End of Uterus > Other tumors > Malignant extrarenal rhabdoid tumor

Ref Updated: 3/5/12


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