Stromomyoma

Uterus
Stromal tumors
Stromomyoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 February 2017, last major update October 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: stromomyoma

Table of Contents

Cite this page: Stromomyoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusstromomyoma.html. Accessed July 16th, 2017.

Definition / general

First described in 1979 (Cancer 1979;43:308)
Also known as combined smooth muscle-stromal tumor
Tumor mass containing up to 1/3 of smooth muscle component
Benign

Case reports

40 year old woman with multiple tumors (Indian J Pathol Microbiol 2008;51:76)
49 year old woman with dysfunctional uterine bleeding (Arch Pathol Lab Med 2005;129:e222)

Gross images

Images hosted on other servers:

Well circumscribed tumor

Microscopic (histologic) description

Well circumscribed, areas resemble sex cord differentiation
Noninfiltrative margin

Microscopic (histologic) images

Images hosted on other servers:

Sharp demarcation with adjacent myometrium

Gross, H&E, alpha
smooth muscle
actin demarcates
leiomyoma-like area

Differential diagnosis

Uterine tumors resembling ovarian sex cord tumors: sex cord elements are immunoreactive for cytokeratin, desmin and sex cord markers calretinin, MelanA, CD99 or inhibin
Endometrial stromal sarcoma - low grade: infiltrative margin, prominent arterioles, Up to 10 - 15 mitotic figures per 10 HPF in most active areas, angiolymphatic invasion common