Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 October 2011, last major update October 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● First described in 1979 (Cancer 1979;43:308)
● Also known as combined smooth muscle-stromal tumor
● Tumor mass containing up to 1/3 of smooth muscle component
● 40 year old woman with multiple tumors (Indian J Pathol Microbiol 2008;51:76)
● 49 year old woman with dysfunctional uterine bleeding (Arch Pathol Lab Med 2005;129:e222)
Well circumscribed tumor
● Well circumscribed, areas resemble sex-cord differentiation
● Noninfiltrative margin
Sharp demarcation with adjacent myometrium
Gross, H&E, alpha smaooth muscle actin demaracates leiomyoma like area
● Uterine tumors resembling ovarian sex cord tumors: sex cord elements are immunoreactive for cytokeratin, desmin and sex cord markers calretinin, MelanA, CD99 or inhibin
● Endometrial stromal sarcoma-low grade: infiltrative margin, prominent arterioles, Up to 10-15 mitotic figures per 10 HPF in most active areas, angiolymphatic invasion common
End of Uterus > Stromal tumors > Stromomyoma
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