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Uterus

Carcinoma

Urothelial carcinoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 March 2012, last major update March 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Rare; < 20 cases
● Mean age 62 years (Cancer 1997;79:1933)
● Usually no gynecologic involvement in pelvic exenterations for bladder urothelial carcinoma (J Urol 2002;168:147)

Case reports
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● Combined with benign ovarian Brenner tumor (Hum Pathol 2001;32:230, Int J Gynecol Pathol 2007;26:298)
● With small areas of endometrioid, glandular differentiation (Int J Gynecol Pathol 2006;25:378)

Micro description
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● Urothelial morphology, almost always mixed with other patterns (squamous, endometrioid, papillary, serous)
● May infiltrate myometrium; variable vascular invasion

Immunostains
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● Usually CK7+/CK20-; less commonly CK7-/CK20-

End of Uterus > Carcinoma > Urothelial carcinoma

Ref Updated: 3/5/12

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