Malignant tumors

Author: Shweta Gera, M.D. (see Authors page)
Editor: Arzu Buyuk, M.D.

Revised: 28 September 2017, last major update June 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Leiomyosarcoma vagina

Cite this page: Gera, S. Leiomyosarcoma. website. Accessed August 19th, 2018.
Definition / general
  • Malignant smooth muscle tumor of vagina
  • Usually originates from smooth muscle of vaginal wall but may develop from smooth muscle cells in tissues near the vagina (J Gynecol Oncol 2008;19:261)
Clinical features
Radiology description
Radiology images

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Preoperative MR images

Prognostic factors
Case reports
Gross description
Microscopic (histologic) description
Microscopic (histologic) images

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Various images

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Appearing in vulva

Cytology description
  • Spindle shaped cells with granular cytoplasm; nuclei are blunt ended, ovoid to elongated, with prominent nucleoli and coarse clumped chromatin
  • Cytoplasm is granular
  • Low grade tumors show more spindle shaped cells in parallel alignment
  • Background necrosis, mitoses with cellular and nuclear pleomorphism are much more frequent in higher grades (Diagn Cytopathol 2003;28:119)
Electron microscopy description
  • Leiomyosarcoma is derived from smooth muscle cells, which is suggested by numerous variously differentiated intermediate cell types including small, intermediate and thick filaments
  • Cytoplasm of more differentiated tumor cells usually contains myofilament bundles (Virchows Arch A Pathol Anat Histol 1975;367:59)
Molecular / cytogenetics description
  • p53 mutation resulting in p53 overexpression