General
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• Benign vulvar and vaginal tumor, first described in 1992 (Am J Surg Pathol 1992;16:373)
• No reported recurrences after excision

Case reports
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• Patient with sarcomatous transformation in vulva (Am J Surg Pathol 1997;21:1104)

Gross description
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• Well circumscribed, 0.5 to 12.0 cm

Micro description
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• Circumscribed tumor with alternating hypercellular and hypocellular areas, spindle cells and plump stroma cells with eosinophilic cytoplasm that aggregate around small blood vessels
• May have binucleated or multinucleated cells
• Minimal stromal mucin, rare/no red blood cell extravasation, no atypia
• Rare/no mitotic figures
• Mast cells common

Positive stains
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• Vimentin, desmin

Negative stains
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• Actin, keratin, S100

Electron microscopy description
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• Well developed rough endoplasmic reticulum, Golgi apparatus, intermediate filaments, pinocytotic vesicles

Differential diagnosis
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• Angiomyxoma: not circumscribed, less cellular, fewer vessels, no hyalinized vessels, stromal mucin, RBC extravasation, infrequent plump stromal cells

Additional references
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• Mod Pathol 1996;9:284

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