General
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• Polyp composed of a central core of fibrous tissue containing irregular shaped thin walled vessels and stellate cells
• The overlying squamous epithelium may display reactive changes, but without papillomatous architecture or koilocytosis

Epidemiology
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• Adult women during pregnancy or neonates

Sites
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• Vagina, vulva

Pathophysiology
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• Due to hormone induced hyperplasia of loose subepithelial connective tissue or end stage of granulation tissue (J Clin Pathol 1992;45:235)

Prognostic factors
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• Benign, may recur during pregnancy

Case reports
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• Five cases (Obstet Gynecol 1976;47:52S)

Treatment
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• Local excision

Gross description
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• Polypoid, multilobulated, and usually solitary

Micro description
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• Central fibrovascular core covered by normal appearing squamous epithelium without intervening Grenz zone
• Stroma may be edematous, hypocellular, or myxoid
• May have atypical stromal cells including stellate and multinucleated cells

Micro images
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Low power

Myxoid stroma and blood vessels

 

Squamous epithelium is focally thickened

Positive stains
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• Desmin, vimentin, ER, PR

Positive stains
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• Actin

Differential diagnosis
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• Angiomyofibroblastoma
• Angiomyxoma
• Botryoid rhabdomyosarcoma: cambium layer, epithelial invasion, rapid growth, cross striations
• Cellular angiofibroma

Additional references
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• Tavassoli: Pathology and Genetics of Tumours of the Breast and Female Genital Organs (2003)

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