Table of Contents
Definition / general | Epidemiology | Sites | Pathophysiology | Prognostic factors | Case reports | Treatment | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Mansouri J. Fibroepithelial stromal polyp. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vaginafibroepithelial.html. Accessed November 23rd, 2020.
Definition / general
- Polyp composed of a central core of fibrous tissue containing irregular shaped thin walled vessels and stellate cells
- Overlying squamous epithelium may display reactive changes but without papillomatous architecture or koilocytosis
Epidemiology
- Adult women during pregnancy or neonates
Sites
- Vagina, vulva
Pathophysiology
- Due to hormone induced hyperplasia of loose subepithelial connective tissue or end stage of granulation tissue (J Clin Pathol 1992;45:235)
Prognostic factors
- Benign, may recur during pregnancy
Case reports
- Five cases (Obstet Gynecol 1976;47:52S)
Treatment
- Local excision
Gross description
- Polypoid, multilobulated and usually solitary
Microscopic (histologic) description
- Central fibrovascular core covered by normal appearing squamous epithelium without intervening Grenz zone
- Stroma may be edematous, hypocellular or myxoid
- May have atypical stromal cells including stellate and multinucleated cells
Negative stains
Differential diagnosis
- Angiomyofibroblastoma
- Angiomyxoma
- Botryoid rhabdomyosarcoma: cambium layer, epithelial invasion, rapid growth, cross striations
- Cellular angiofibroma
