Vagina
Malignant tumors
Mesonephric adenocarcinoma



Senior Author: Arzu Buyuk, M.D.

Topic Completed: 1 September 2014

Revised: 26 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Mesonephric adenocarcinoma vagina
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Cite this page: Gera S. Mesonephric adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vaginamesonephricadeno.html. Accessed March 22nd, 2019.
Definition / general
  • Exceptionally rare primary adenocarcinoma of vagina arising from mesonephric remnants
Epidemiology
Sites
Pathophysiology
  • Mesonephric ducts run along broad ligament, lateral walls of uterus and cervix and extend deep in lateral walls of vagina (Gartner ducts)
  • In females, the Wolffian ducts eventually regress but their remnants give rise to rete ovarii, paraoophoron, Gartner duct
Etiology
Clinical features
Radiology description
  • Imaging (CT scan and MRI) to assess tumor stage and metastasis
Prognostic factors
Treatment
  • If tumor is encapsulated / well circumscribed: total abdominal hysterectomy with salpingo-oophorectomy
  • Adjuvant therapy (radiotherapy, chemotherapy)
Gross description
Microscopic (histologic) description
  • Ductal and tubular structures
  • Ductal structures are lined by low cuboidal to tall columnar cells with scanty pale to eosinophilic cytoplasm and nuclear pleomorphism; can have endometrioid-like appearance
  • Tubular structures are small, round, relatively uniform tubules with some angulation, lined by cuboidal or flattened cells containing dense eosinophilic amorphous material; tubules generally are closely packed; may have thick collagen bands between tubular structures
  • Prominent nucleoli and atypical mitoses can be present; also adjacent benign appearing mesonephric remnant hyperplasia (Gynecol Oncol 2005;99:757)
Microscopic (histologic) images

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H&E

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Round glandular structures

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Immunostains

Cytology description
  • Nonspecific adenocarcinoma features (hyperchromatic nuclei, high nuclear to cytoplasmic ratio, prominent nucleoli)
Positive stains
Differential diagnosis
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