Malignant tumors
Mesonephric adenocarcinoma

Author: Shweta Gera, M.D. (see Authors page)
Editor: Arzu Buyuk, M.D.

Revised: 29 September 2017, last major update September 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Mesonephric adenocarcinoma vagina

Cite this page: Gera, S. Mesonephric adenocarcinoma. website. Accessed August 19th, 2018.
Definition / general
  • Exceptionally rare primary adenocarcinoma of vagina arising from mesonephric remnants
  • Mesonephric ducts run along broad ligament, lateral walls of uterus and cervix and extend deep in lateral walls of vagina (Gartner ducts)
  • In females, the Wolffian ducts eventually regress but their remnants give rise to rete ovarii, paraoophoron, Gartner duct
Clinical features
Radiology description
  • Imaging (CT scan and MRI) to assess tumor stage and metastasis
Prognostic factors
  • If tumor is encapsulated / well circumscribed: total abdominal hysterectomy with salpingo-oophorectomy
  • Adjuvant therapy (radiotherapy, chemotherapy)
Gross description
Microscopic (histologic) description
  • Ductal and tubular structures
  • Ductal structures are lined by low cuboidal to tall columnar cells with scanty pale to eosinophilic cytoplasm and nuclear pleomorphism; can have endometrioid-like appearance
  • Tubular structures are small, round, relatively uniform tubules with some angulation, lined by cuboidal or flattened cells containing dense eosinophilic amorphous material; tubules generally are closely packed; may have thick collagen bands between tubular structures
  • Prominent nucleoli and atypical mitoses can be present; also adjacent benign appearing mesonephric remnant hyperplasia (Gynecol Oncol 2005;99:757)
Microscopic (histologic) images

Images hosted on other servers:
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Round glandular structures

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Cytology description
  • Nonspecific adenocarcinoma features (hyperchromatic nuclei, high nuclear to cytoplasmic ratio, prominent nucleoli)
Positive stains
Differential diagnosis