Vagina
Malignant tumors
Rhabdomyosarcoma, embryonal (boytroid)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 October 2017, last major update March 2003

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma vagina [title]

Cite this page: Pernick, N. Rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vaginarms.html. Accessed October 19th, 2017.
Definition / general
  • Most common malignant soft tissue tumor in children and adolescents
  • 6% of all malignancies in children; 20% occur in pelvic portion of GU tract
  • Usually embryonal or botryoid subtype
  • 10 year survival is 73% for classic embryonal subtype
  • Histologic maturation after treatment often occurs but these cells may be malignant
  • Botyroid variant of embryonal rhabdomyosarcoma is also known as sarcoma botryoides
    • Usually children < 5 years (2/3 under age 2) in anterior vaginal wall
Treatment
Gross description
  • Grape-like clusters that fill and project out vagina
Microscopic (histologic) description
  • Small tumor cells with oval nuclei, cytoplasm protrudes from one end
  • Resemble tennis rackets with bright, eosinophilic granular cytoplasm suggesting of rhabdomyoblastic differentiation
  • May lack cross striations
  • Tumor cells crowded into cambium layer beneath intact vaginal epithelium and around blood vessels
  • In deep regions, lie within loose, fibromyxoid stroma with edema and inflammatory cells
  • May invade overlying epithelium
  • Neoplastic cartilage seen in older patients, may be associated with a better prognosis
Positive stains
Differential diagnosis