Vagina
Malignant tumors
Rhabdomyosarcoma, embryonal (boytroid)




Topic Completed: 1 March 2003

Revised: 26 February 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma vagina [title]
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Cite this page: Pernick N. Rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vaginarms.html. Accessed April 18th, 2019.
Definition / general
  • Most common malignant soft tissue tumor in children and adolescents
  • 6% of all malignancies in children; 20% occur in pelvic portion of GU tract
  • Usually embryonal or botryoid subtype
  • 10 year survival is 73% for classic embryonal subtype
  • Histologic maturation after treatment often occurs but these cells may be malignant
  • Botyroid variant of embryonal rhabdomyosarcoma is also known as sarcoma botryoides
    • Usually children < 5 years (2/3 under age 2) in anterior vaginal wall
Treatment
Gross description
  • Grape-like clusters that fill and project out vagina
Microscopic (histologic) description
  • Small tumor cells with oval nuclei, cytoplasm protrudes from one end
  • Resemble tennis rackets with bright, eosinophilic granular cytoplasm suggesting of rhabdomyoblastic differentiation
  • May lack cross striations
  • Tumor cells crowded into cambium layer beneath intact vaginal epithelium and around blood vessels
  • In deep regions, lie within loose, fibromyxoid stroma with edema and inflammatory cells
  • May invade overlying epithelium
  • Neoplastic cartilage seen in older patients, may be associated with a better prognosis
Positive stains
Differential diagnosis
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