Vulva, vagina & female urethra
Squamous carcinoma and precursor lesions
Spindle cell (sarcomatoid) carcinoma

Topic Completed: 1 October 2014

Minor changes: 13 August 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Vagina spindle cell sarcomatoid carcinoma

Shweta Gera, M.D.
Page views in 2019: 2,062
Page views in 2020 to date: 1,729
Cite this page: Gera S. Spindle cell (sarcomatoid) carcinoma. website. Accessed October 24th, 2020.
Definition / general
  • Variant of squamous cell carcinoma with spindle cell morphology, associated with poor prognosis
  • Squamous cell carcinoma with sarcoma-like stroma, pseudosarcoma (Cancer 1983;52:890)
  • Sarcomatoid squamous cell carcinoma
  • High risk human papillomavirus (HPV) subtypes have a role in carcinogenesis
Clinical features
  • Pelvic pain, vaginal discharge (Cancer 1983;52:890)
  • Vaginal bleeding and obstructive symptoms can occur due to mass effect
  • Based on clinical, radiological and thorough pathological examination
Radiology description
  • Imaging required to stage the disease and look for metastasis
Prognostic factors
Case reports
Gross description
Microscopic (histologic) description
  • Fascicles of plump spindle cells with homogenous to fibrillar cytoplasm, round to oval vesicular nuclei with multiple nucleoli and numerous mitotic figures
  • Usually tumor will also have well to moderately differentiated squamous cell component, which can be easily missed on a biopsy
  • Therefore thorough sampling recommended (Cancer 1983;52:890, Gynecol Oncol 1993;49:100)
Electron microscopy description
Additional references
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