Malignant tumors
Urothelial carcinoma

Senior Author: Arzu Buyuk, M.D.
Shweta Gera, M.D.

Topic Completed: 1 December 2014

Revised: 26 February 2019

Copyright: 2002-2017,, Inc.

PubMed Search: Urothelial carcinoma vagina

Shweta Gera, M.D.
Page views in 2018: 689
Page views in 2019 to date: 736
Cite this page: Gera S. Urothelial carcinoma. website. Accessed September 23rd, 2019.
Definition / general
  • Primary urothelial carcinoma arising in vagina with no evidence of direct extension or metastasis from lower urinary tract or urinary bladder or implantation by irrigation fluid of transurethral resection or transfer of urine
  • Primary vaginal urothelial carcinoma
  • Pathogenesis is unclear but direct extension or metastasis from bladder urothelial carcinoma needs to be ruled out
  • Both vagina and urinary bladder are embryologically derived from urogenital sinus
  • May derive from common vaginal stem cell line containing an immature cell with pluripotent capacity during development (Int J Clin Oncol 2010;15:626)
  • May originate from urothelial / transitional cell metaplasia of vaginal squamous epithelium (Int J Gynaecol Obstet 2011;115:292)
Clinical features
  • Vaginal bleeding
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:
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Neoplastic cells in sheets and trabeculae

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Cells arranged around central vascular core

Cytology description
  • Specimen is usually highly cellular with tumor cells arranged singly and in loose three dimensional clusters, with overlapping nuclei
  • Tumor cells are large and polygonal with well defined cell borders, high nuclear to cytoplasmic ratio, granular basophilic cytoplasm, coarse chromatin and conspicuous nucleoli
  • Scattered keratinized single cells with atypical hyperchromatic nuclei can also be present
  • Shares many morphologic features with primary squamous cell carcinoma of vagina, including focal keratinization (Diagn Cytopathol 2012;40:168)
Differential diagnosis
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