Vulva & female urethra
Other tumors

Topic Completed: 1 June 2013

Revised: 6 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Vulva angiomyofibroblastoma

Kelli Hutchens, M.D.
Page views in 2018: 3,712
Page views in 2019 to date: 3,015
Cite this page: Hutchens K. Angiomyofibroblastoma. website. Accessed September 22nd, 2019.
Definition / general
  • Often abbreviated AMF or AMFB
  • Usually middle aged females (fourth and fifth decades of life)
  • Rare single case reports in young (ages 17 - 25) or elderly women (age 80)
  • Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area
  • Likely derived from subepithelial myxoid stromal zone of vagina and vulva
Clinical features
  • Slow growing mass, occasionally pedunculated
  • Diagnose with biopsy or excision
Case reports
  • Complete excision is curative
Clinical images

Images hosted on other servers:

Pedunculated large mass arising from labia minora

Gross description
  • Well circumscribed mass, 1 cm to 15 cm
  • Homogenous pink gray cut surface with no necrosis or hemorrhage
Microscopic (histologic) description
  • Encapsulated tumor with hyper and hypocellular areas and numerous vessels
  • Vessels may be hyalinized
  • Hypercellular areas composed of plump stromal cells that often congregate around vessels
  • Hypocellular areas are more spindled
  • Rarely mitotic figures and multinucleated cells
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #241:



Smooth muscle actin


Positive stains
Negative stains
Differential diagnosis
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