Benign tumors

Author: Kelli A. Hutchens, M.D. (see Authors page)

Revised: 10 August 2018, last major update June 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Vulva angiomyofibroblastoma

Page views in 2018: 3,712
Page views in 2019 to date: 233
Cite this page: Hutchens, K.A. Angiomyofibroblastoma. website. Accessed January 21st, 2019.
Definition / general
  • Often abbreviated AMF or AMFB
  • Usually middle aged females (fourth and fifth decades of life)
  • Rare single case reports in young (ages 17 - 25) or elderly women (age 80)
  • Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area
  • Likely derived from subepithelial myxoid stromal zone of vagina and vulva
Clinical features
  • Slow growing mass, occasionally pedunculated
  • Diagnose with biopsy or excision
Case reports
  • Complete excision is curative
Clinical images

Images hosted on other servers:

Pedunculated large mass arising from labia minora

Gross description
  • Well circumscribed mass, 1 cm to 15 cm
  • Homogenous pink gray cut surface with no necrosis or hemorrhage
Microscopic (histologic) description
  • Encapsulated tumor with hyper and hypocellular areas and numerous vessels
  • Vessels may be hyalinized
  • Hypercellular areas composed of plump stromal cells that often congregate around vessels
  • Hypocellular areas are more spindled
  • Rarely mitotic figures and multinucleated cells
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #241:



Smooth muscle actin


Positive stains
Negative stains
Differential diagnosis