Vulva, vagina & female urethra
Vulva & vagina
Other tumors
Angiomyofibroblastoma
Author: Kelli Hutchens, M.D.
Topic Completed: 1 June 2013
Minor changes: 20 August 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Vulva angiomyofibroblastoma
Table of Contents
Definition / general | Terminology | Epidemiology | Sites | Pathophysiology | Clinical features | Case reports | Treatment | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Hutchens K. Angiomyofibroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vulvaangiomyofibroblastoma.html. Accessed September 23rd, 2020.
Definition / general
- See also topic to be merged
- Benign mesenchymal tumor (Mod Pathol 1996;9:284)
Terminology
- Often abbreviated AMF or AMFB
Epidemiology
- Usually middle aged females (fourth and fifth decades of life)
- Rare single case reports in young (ages 17 - 25) or elderly women (age 80)
Sites
- Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area
Pathophysiology
- Likely derived from subepithelial myxoid stromal zone of vagina and vulva
Clinical features
- Slow growing mass, occasionally pedunculated
- Diagnose with biopsy or excision
Case reports
- 21 year old woman with pedunculated angiomyofibroblastoma involving labia minora (Case Rep Med 2011;2011:893261)
- 30 year old woman with 2 cm circumscribed mass (Case of the Week #241)
- 40 year old man with angiomyofibroblatoma-like tumor of scrotum (Turk Patoloji Derg 2012;28:168)
- 80 year old woman with sarcomatous transformation (Am J Surg Pathol 1997;21:1104)
Treatment
- Complete excision is curative
Clinical images
Images hosted on other servers:
Pedunculated large mass arising from labia minora
Gross description
- Well circumscribed mass, 1 cm to 15 cm
- Homogenous pink gray cut surface with no necrosis or hemorrhage
Microscopic (histologic) description
- Encapsulated tumor with hyper and hypocellular areas and numerous vessels
- Vessels may be hyalinized
- Hypercellular areas composed of plump stromal cells that often congregate around vessels
- Hypocellular areas are more spindled
- Rarely mitotic figures and multinucleated cells
Microscopic (histologic) images
Case #241
CD34
Desmin
Smooth muscle actin
Vimentin
Negative stains
Differential diagnosis
- Aggressive angiomyxoma: less cellular, is locally invasive
- Bartholin cyst: resembles clinically
