Vulva
Benign tumors
Angiomyofibroblastoma

Author: Kelli A. Hutchens, M.D. (see Authors page)

Revised: 4 October 2017, last major update June 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Vulva angiomyofibroblastoma

Cite this page: Hutchens, K.A. Angiomyofibroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vulvaangiomyofibroblastoma.html. Accessed November 19th, 2017.
Definition / general
Terminology
  • Often abbreviated AMF or AMFB
Epidemiology
  • Usually middle aged females (fourth and fifth decades of life)
  • Rare single case reports in young (ages 17 - 25) or elderly women (age 80)
Sites
  • Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area
Pathophysiology
  • Likely derived from subepithelial myxoid stromal zone of vagina and vulva
Clinical features
  • Slow growing mass, occasionally pedunculated
  • Diagnose with biopsy or excision
Case reports
Treatment
  • Complete excision is curative
Clinical images

Images hosted on other servers:

Pedunculated large mass arising from labia minora

Gross description
  • Well circumscribed mass, 1 cm to 15 cm
  • Homogenous pink gray cut surface with no necrosis or hemorrhage
Gross images

Images hosted on other servers:

Vulva

Microscopic (histologic) description
  • Encapsulated tumor with hyper and hypocellular areas and numerous vessels
  • Vessels may be hyalinized
  • Hypercellular areas composed of plump stromal cells that often congregate around vessels
  • Hypocellular areas are more spindled
  • Rarely mitotic figures and multinucleated cells
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #241:


CD34

Desmin

Smooth muscle actin

Vimentin

Positive stains
Negative stains
Differential diagnosis