Definition
=========================================================================

• Benign mesenchymal tumor (Mod Pathol 1996;9:284)

Terminology
=========================================================================

• Often abbreviated AMF or AMFB

Epidemiology
=========================================================================

• Usually middle aged females (fourth and fifth decades of life)
• Rare single case reports in young (ages 17-25) or elderly women (age 80)

Sites
=========================================================================

• Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area

Pathophysiology
=========================================================================

• Likely derived from subepithelial myxoid stromal zone of vagina and vulva

Clinical features
=========================================================================

• Slow growing mass, occasionally pedunculated
• Diagnose with biopsy or excision

Case reports
=========================================================================

• 21 year old woman with pedunculated angiomyofibroblastoma involving labia minora (Case Rep Med 2011;2011:893261)
• 30 year old woman with 2 cm circumscribed mass (Case of the Week #241)
• 40 year old man with angiomyofibroblatoma-like tumor of scrotum (Turk Patoloji Derg 2012;28:168)
• 80 year old woman with sarcomatous transformation (Am J Surg Pathol 1997;21:1104)

Treatment
=========================================================================

• Complete excision is curative

Clinical images
=========================================================================

Pedunculated large mass arising from labia minora

Gross description
=========================================================================

• Well circumscribed mass, 1 cm to 15 cm
• Homogenous pink-gray cut surface with no necrosis or hemorrhage

Gross images
=========================================================================

Vulva

Micro description
=========================================================================

• Encapsulated tumor with hyper- and hypocellular areas and numerous vessels
• Vessels may be hyalinized
• Hypercellular areas composed of plump stromal cells that often congregate around vessels
• Hypocellular areas are more spindled
• Rarely mitotic figures and multinucleated cells

Micro images
=========================================================================

CD34

Desmin

Smooth muscle actin

Vimentin

Positive stains
=========================================================================

• Vimentin, desmin, ER and PR receptor
• Weak or patchy staining for CD34

Negative stains
=========================================================================

• S100, pankeratin

Differential diagnosis
=========================================================================

• Aggressive angiomyxoma: less cellular, is locally invasive
• Bartholin cyst: resembles clinically

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).