Angiomyofibroblastoma

Vulva
Benign tumors
Angiomyofibroblastoma

Author: Kelli A. Hutchens, M.D. (see Authors page)

Revised: 10 August 2018, last major update June 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Vulva angiomyofibroblastoma

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Table of Contents

Cite this page: Hutchens, K.A. Angiomyofibroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vulvaangiomyofibroblastoma.html. Accessed January 21st, 2019.

Definition / general

Benign mesenchymal tumor (Mod Pathol 1996;9:284)

Terminology

Often abbreviated AMF or AMFB

Epidemiology

Usually middle aged females (fourth and fifth decades of life)
Rare single case reports in young (ages 17 - 25) or elderly women (age 80)

Sites

Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area

Pathophysiology

Likely derived from subepithelial myxoid stromal zone of vagina and vulva

Clinical features

Slow growing mass, occasionally pedunculated
Diagnose with biopsy or excision

Case reports

21 year old woman with pedunculated angiomyofibroblastoma involving labia minora (Case Rep Med 2011;2011:893261)
30 year old woman with 2 cm circumscribed mass (Case of the Week #241)
40 year old man with angiomyofibroblatoma-like tumor of scrotum (Turk Patoloji Derg 2012;28:168)
80 year old woman with sarcomatous transformation (Am J Surg Pathol 1997;21:1104)

Treatment

Complete excision is curative

Clinical images

Images hosted on other servers:

Pedunculated large mass arising from labia minora

Gross description

Well circumscribed mass, 1 cm to 15 cm
Homogenous pink gray cut surface with no necrosis or hemorrhage

Microscopic (histologic) description

Encapsulated tumor with hyper and hypocellular areas and numerous vessels
Vessels may be hyalinized
Hypercellular areas composed of plump stromal cells that often congregate around vessels
Hypocellular areas are more spindled
Rarely mitotic figures and multinucleated cells

Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #241: