Definition
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• Benign mesenchymal tumor (Mod Pathol 1996;9:284)

Terminology
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• Often abbreviated AMF or AMFB

Epidemiology
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• Usually middle aged females (fourth and fifth decades of life)
• Rare single case reports in young (ages 17-25) or elderly women (age 80)

Sites
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• Usually vulvovaginal area (70 cases in vulva); rare in scrotum or male inguinal area

Pathophysiology
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• Likely derived from subepithelial myxoid stromal zone of vagina and vulva

Clinical features
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• Slow growing mass, occasionally pedunculated
• Diagnose with biopsy or excision

Case reports
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• 21 year old woman with pedunculated angiomyofibroblastoma involving labia minora (Case Rep Med 2011;2011:893261)
• 30 year old woman with 2 cm circumscribed mass (Case of the Week #241)
• 40 year old man with angiomyofibroblatoma-like tumor of scrotum (Turk Patoloji Derg 2012;28:168)
• 80 year old woman with sarcomatous transformation (Am J Surg Pathol 1997;21:1104)

Treatment
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• Complete excision is curative

Clinical images
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Pedunculated large mass arising from labia minora

Gross description
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• Well circumscribed mass, 1 cm to 15 cm
• Homogenous pink-gray cut surface with no necrosis or hemorrhage

Gross images
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Vulva

Micro description
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• Encapsulated tumor with hyper- and hypocellular areas and numerous vessels
• Vessels may be hyalinized
• Hypercellular areas composed of plump stromal cells that often congregate around vessels
• Hypocellular areas are more spindled
• Rarely mitotic figures and multinucleated cells

Micro images
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CD34

Desmin

Smooth muscle actin

Vimentin

Positive stains
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• Vimentin, desmin, ER and PR receptor
• Weak or patchy staining for CD34

Negative stains
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• S100, pankeratin

Differential diagnosis
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• Aggressive angiomyxoma: less cellular, is locally invasive
• Bartholin cyst: resembles clinically

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