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General
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Epidemiology
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Sites
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Clinical features
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Diagnosis
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Laboratory
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Radiology
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Prognostic factors
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Case reports
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Treatment
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Clinical images
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CT scan, enlarged lymph node

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Nodule and ulcer

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Large friable, grey white growth

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Vulvar melanoma

Gross description
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Micro description
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Micro images
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Pleomorphic spindled to epitheloid cells

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Cells in sheets

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HMB45+



Courtesy of Priya Nagarajan, M.D:

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Melanoma in situ

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Melanoma in situ vs
atypical >melanocytic
hyperplasia

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Mostly in-situ, minimal invasive component

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Invasive and in situ melanoma

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Polypoid melanoma: low to intermediate magnification

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High magnification

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Melanoma with ulceration

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Heavily pigmented

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Recurrence in subcutaneous fibroadipose tissue

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Isolated nodal metastases

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Melan A (three images)

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SOX10



Positive stains
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Negative stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Vulva > Malignant neoplasms > Melanoma



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