Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 10 October 2013, last major update October 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: Vulva multinucleated atypia
- Histologic pattern of multinucleated keratinocytes in basal and middle layers of squamous epithelium of vulva (Am J Surg Pathol 1994;18:1233)
- May mimic human papillomavirus (HPV)-related squamous dysplasia, but not associated with HPV
- May present as flesh colored vulvar papules
- Multinucleated keratinocytes without significant nuclear atypia in lower to middle epithelial layers of otherwise normal appearing squamous epithelium
- These multinucleated cells may contain 2-10 nuclei, often prominent nucleoli
- No surface atypia, no hyperchromasia, no pleomorphism
- No significant inflammation
End of Vulva > Non-neoplastic disorders > Multinucleated atypia
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