Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Negative stainsCite this page: Roychowdhury, M. Multinucleated atypia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/vulvamultinucleatedatypia.html. Accessed April 19th, 2018.
Definition / general
- Histologic pattern of multinucleated keratinocytes in basal and middle layers of squamous epithelium of vulva (Am J Surg Pathol 1994;18:1233)
- May mimic human papillomavirus (HPV) related squamous dysplasia but not associated with HPV
Case reports
- 49 year old woman (Cutis 2005;75:118)
Gross description
- May present as flesh colored vulvar papules
Microscopic (histologic) description
- Multinucleated keratinocytes without significant nuclear atypia in lower to middle epithelial layers of otherwise normal appearing squamous epithelium
- These multinucleated cells may contain 2 - 10 nuclei, often prominent nucleoli
- No surface atypia, no hyperchromasia, no pleomorphism
- No significant inflammation
Negative stains
- HPV, HSV