General
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• Histologic pattern of multinucleated keratinocytes in basal and middle layers of squamous epithelium of vulva (Am J Surg Pathol 1994;18:1233)
• May mimic human papillomavirus (HPV)-related squamous dysplasia, but not associated with HPV

Case reports
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• 49 year old woman (Cutis 2005;75:118)

Gross description
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• May present as flesh colored vulvar papules

Micro description
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• Multinucleated keratinocytes without significant nuclear atypia in lower to middle epithelial layers of otherwise normal appearing squamous epithelium
• These multinucleated cells may contain 2-10 nuclei, often prominent nucleoli
• No surface atypia, no hyperchromasia, no pleomorphism
• No significant inflammation

Negative stains
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• HPV, HSV

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