Nonneoplastic disorders
Multinucleated atypia

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 4 October 2017, last major update October 2013

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Vulvar multinucleated atypia

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Cite this page: Roychowdhury, M. Multinucleated atypia. website. Accessed January 22nd, 2019.
Definition / general
  • Histologic pattern of multinucleated keratinocytes in basal and middle layers of squamous epithelium of vulva (Am J Surg Pathol 1994;18:1233)
  • May mimic human papillomavirus (HPV) related squamous dysplasia but not associated with HPV
Case reports
Gross description
  • May present as flesh colored vulvar papules
Microscopic (histologic) description
  • Multinucleated keratinocytes without significant nuclear atypia in lower to middle epithelial layers of otherwise normal appearing squamous epithelium
  • These multinucleated cells may contain 2 - 10 nuclei, often prominent nucleoli
  • No surface atypia, no hyperchromasia, no pleomorphism
  • No significant inflammation
Negative stains