General
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• This topic covers unusual neoplasms of the vulva

Case reports
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• Unusual carcinomas:
  • 43 year old woman with microcystic adnexal carcinoma of vulva (Gynecol Oncol 2001;82:571)
  • 48 year old woman with eccrine porocarcinoma of vulva (Int J Gynecol Pathol 2011;30:95)
  • 58 year old woman with malignant spiradenoma/cylindroma of vulva (Saudi Med J 2012;33:1229)
  • 67 year old and another woman with primary apocrine carcinoma of vulva (Rare Tumors 2013;5:e40, Pathol Res Pract 2009;205:131) )
  • 69 year old woman with eccrine porocarcinoma with carcinomatous lymphangitis (Int J Surg Pathol 2012;20:515)
  • 80 year old woman with collision vulvar tumor composed of mammary-type myofibroblastoma and eccrine adenocarcinoma (Pathol Int 2011;61:138)
  • Anogenital sweat gland adenocarcinoma of vulva (Am J Dermatopathol 2012;34:773)
  • Eccrine carcinoma (nodular porocarcinoma) of vulva (Histopathology 2005;47:324)
  
  
• Vascular tumors:
  • 74 year old woman with epithelioid angiosarcoma of the mons (Int J Gynecol Pathol 2007;26:265)
  • Angiosarcomas of primary gynecologic origin (Int J Gynecol Cancer 2014;24:4)
  • Vascular tumors of the female genital tract (Eur J Gynaecol Oncol 2003;24:48)
  
  
• Other sarcomas:
  • Chondrosarcoma: 24 year old woman with myxoid subtype (J Obstet Gynaecol Res 2011;37:1706), 68 year old woman with tumor of labium majus (Case Rep Pathol 2011;2011:429562), 3 patients with mesenchymal subtype (Obstet Gynecol Sci 2013;56:345), myxoid subtype with PLAG1 gene activation (Appl Immunohistochem Mol Morphol 2014;22:537), NR4A3 to distinguish myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma (Virchows Arch 2012;460:621)
  • Ewing sarcoma / primitive neuroectodermal tumor (PNET): 28 year old woman (J Med Liban 2012;60:113), 37 year old woman (J Obstet Gynaecol Res 2013;39:746), 2 cases in young women (Int J Gynecol Cancer 2009;19:1131)
  • Malignant peripheral nerve sheath tumor/MPNST: 34 year old woman (Gynecol Oncol 2002;85:365), 52 year old woman (Int J Surg Case Rep 2014;5:793), 81 year old woman (J Reprod Med 2002;47:721)
  • Synovial sarcoma: 28 year old woman (J Med Case Rep 2011;5:95), 32 year old woman with monophasic subtype (Arch Pathol Lab Med 2008;132:698), confirmed by FISH (Oncol Lett 2012;4:955), 3 cases (Int J Gynecol Pathol 2011;30:84)
  
  
• Lymphoma and hematopoietic tumors:
  • CLL: 55 year old woman (J Gynecol Oncol 2012;23:205)
  • Diffuse large B cell lymphoma: 83 year old woman (Clin Nucl Med 2014;39:e439), 87 year old woman with vulvar metastasis as initial presentation (J Reprod Med 2007;52:1065), various cases (Int J Gynecol Pathol 2000;19:236)
    
  • Hodgkin lymphoma: 45 year old woman with lymphoma presenting as vulvar mass (J Low Genit Tract Dis 2009;13:110)
  • Lymphomatoid granulomatosis of vulva (J Obstet Gynaecol 2009;29:255)
  • Marginal zone lymphoma: 80 year old woman with transformation of vulvar pseudolymphoma (J Obstet Gynaecol Res 2008;34:699)
  • Myeloid sarcoma: 16 year old girl with isolated vaginal tumor (Ann Diagn Pathol 2012;16:374), 41 year old woman with tumor post-bone marrow transplant (Hematol Oncol Stem Cell Ther 2012;5:118), 77 year old woman (J Low Genit Tract Dis 2010;14:136)
  • T cell lymphoma: 48 year old woman with intravascular lymphoma (Eur J Gynaecol Oncol 2009;30:586)
  
  
• Adipocytic tumors:
  • Benign lipoblastoma-like tumor of vulva: 15 year old girl (J Reprod Med 2007;52:223), 3 cases (Histopathology 2002;40:505)
    
  • Spindle cell / pleomorphic lipoma of vulva: 56 year old woman (J Cutan Pathol 2002;29:59)
  • Liposarcoma: 37 year old woman with bilateral tumors (Obstet Gynecol Sci 2014;57:549), myxoid liposarcoma and well differentiated liposarcoma with molecular cytogenetic confirmation (Int J Gynecol Pathol 2015 Apr 1 [Epub ahead of print]), 6 cases (Int J Gynecol Pathol 1998;17:17)
  
  
• Fibrocytic / myofibroblastic tumors:
  • 36 year old and another woman with low-grade fibromyxoid sarcoma of vulva (J Low Genit Tract Dis 2013;17:79 (J La State Med Soc 2012;164:95)
  • 40 year old woman with nodular fasciitis of vulva (Pathol Res Pract 1998;194:805)
  • Desmoid tumor of vulva (J Reprod Med 1999;44:748)
  • Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract (Am J Surg Pathol 2000;24:231)
  
  
• Fibrohistiocytic tumors:
  • Dermatofibrosarcoma protuberans/DFSP: 31 year and 38 year old women with coexisting giant cell fibroblastoma (Pathol Res Pract 2001;197:263, Eur J Gynaecol Oncol 2010;31:685), case report (J Obstet Gynaecol 2015;35:209), 13 cases (Am J Surg Pathol 2010;34:393)
  
  
• Myogenic tumors:
  • Rhabdomyosarcoma: 17 year old girl with alveolar subtype (Indian J Pathol Microbiol 2010;53:167), embryonal subtype (J Pediatr Urol 2013;9:e144), tumors of clitoris (Hematol Oncol Stem Cell Ther 2008;1:133, Pediatr Radiol 2007;37:1179)

Micro images
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Apocrine adenocarcinoma

Chondrosarcoma, mesenchymal

Chronic lymphocytic leukemia

Liposarcoma

 

MPNST, epithelioid and spindle cells

 

Rhabdomyosarcoma, alveolar

Synovial sarcoma

Additional references (vulvar tumors)
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• Low grade fibromyxoid sarcoma: Am J Surg Pathol 2005;29:204
• Mycosis fungoides: Dermatol Ther 2015;28:36
• Rhabdomyosarcoma: Am J Surg Pathol 2007;31:382
• Sarcomas: Int J Immunopathol Pharmacol 2015 Mar 26 [Epub ahead of print], Int J Immunopathol Pharmacol 2015 Mar 26 [Epub ahead of print]

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