Nonneoplastic disorders
Perineal nodular induration

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 October 2017, last major update September 2014

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Perineal nodular induration

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Cite this page: Pernick, N. Perineal nodular induration. website. Accessed January 21st, 2019.
Definition / general
Case reports
  • 34 year old female cyclist with perineal cysts (Case of the Week #326)
  • In women, a recent report describes 4 cases of unilateral nodules or swellings of the labium major in competitive cyclists ages 15 - 45 years (Am J Surg Pathol 2011;35:110)
Microscopic (histologic) description
Case of the Week #326:
  • Mixture of adipose tissue, hyalinized tissue with bland spindled fibroblasts, blood vessels and nerve fibers, with variable perivascular lymphocytic infiltrate, thick cords of fibrous tissue, elastic fibers and epithelioid, plasmacytoid or ganglion-like cells
  • Spindle cells cells were immunoreactive for estrogen receptor and plump mesenchymal cells were positive for smooth muscle actin, consistent with myofibroblasts
  • These cells were negative for desmin, S100, CD34 (but see Int J Surg Pathol 2014;22:71) and HMGA2
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #326:

H&E images