General
=========================================================================

• Resemble fibroepithelial stromal polyps of vagina, cervix and vulva, but with bizarre morphology, frequent mitoses (>10/10 HPF), atypical mitotic figures or hypercellularity
• Median age 32, range 16-75 years
• Often in pregnant patients
• May recur locally; no metastases
• Positive margin status, which is common, apparently not associated with recurrence

Gross description
=========================================================================

• Often multiple lesions, particularly in pregnant women

Positive stains
=========================================================================

• Desmin

Differential diagnosis
=========================================================================

• Aggressive angiomyxoma: deep, prominent vascular pattern cuffed by myoid bundles
• Angiomyofibroblastoma: well circumscribed subserosal nodule, no atypia, stromal cells cluster around vessels, which usually have delicate walls
• Botyroid embryonal rhabdomyosarcoma: early childhood, submucosal hypercellular zone/cambium layer, rhabdomyoblasts, myoglobin+, myogenin+
• Cellular angiofibroma: well circumscribed, less polypoid, diffusely vascular with hyalinized walls, no atypical stromal cells, desmin-
• DFSP: CD34+, desmin-, storiform throughout
• Leiomyosarcoma: clear boundary of tumor cells with epithelium, smooth muscle differentiation
• Low grade endometrial stromal sarcoma: vessels resemble spiral arterioles, no central vascular core, thick bands of collagen in starburst pattern, dot like staining of desmin or keratin
• MPNST: perivascular accentuation, 50% are S100+

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).