30 November 2005 Case of the Week #29


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We thank Dr. Jason Hicks, Harris Methodist H.E.B., Bedford, Texas (USA) for contributing this case. We invite you to contribute a Case of the Week by sending an email to NPernick@PathologyOutlines.com with microscopic images (any size, we will shrink if necessary) in JPG or GIF format, a short clinical history, your diagnosis and any other images (gross, immunostains, EM, etc.) that you have and that may be helpful or interesting. We will write the discussion (unless you want to), list you as the contributor, and send you a check for $35 (US) for your time after we send out the case. Please only send cases with a definitive diagnosis.


Case of the Week #29


Clinical History


A 33 year old woman had a 2.4 cm. soft tissue mass of the cheek.  Her past medical history was remarkable only for a remote mitral valve replacement. The mass had been present for a while, but recently grew in size prompting a visit to her doctor. 


Gross description: The specimen contained a 2.4 cm, subcutaneous, rubbery, pink-tan mass with an elliptical strip of pale overlying skin.


Micro description: low power #1; #2; #3; high power


Immunohistochemistry: CD34 positive; negative for Factor XIIIa and CD68


What is your diagnosis?


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Solitary fibrous tumor of the dermis




Solitary fibrous tumor was originally reported in the pleura, but has since been reported at almost all organ and body sites. In the skin, they are well circumscribed dermal lesions, composed of spindle cells in a patternless pattern of short and narrow fascicles. There are intermixed bundles of thick collagen, and numerous blood vessels which may have a hemangiopericytoma-like, staghorn pattern. Variable features include hypocellular and hypercellular areas and myxoid areas. Tumor cells are immunoreactive for CD34, vimentin and bcl2, and negative for Factor XIIIa, CD68, neural, smooth muscle and epithelial markers. Excision is curative, as these tumors almost always have benign behavior.


The differential diagnosis includes other spindled tumors of the skin. One uncommon mimic is a CD34-reactive dermal dendrocytoma, which is also a benign, well circumscribed tumor composed of CD34+ spindle cells and collagen fibers, with a loose fascicular pattern. However, the collagen fibers are thin, not thick, and the background is invariably myxoid. In addition, its tumor cells are CD68+, in contrast to CD68- tumor cells in solitary fibrous tumor (Am J Dermatopathol 2002;24:50).


Additional references: Am J Dermatopathol 1999;21:213


Case reports: 56 year old woman with nodule in cheek (J Am Acad Dermatol 2002;46(2 Suppl Case Reports):S37), 30 month old girl with aggressive scalp lesion (Pediatr Dev Pathol 2001;4:267), 37 year old woman with scalp lesion (Am J Dermatopathol 1997;19:515)



Nat Pernick, M.D.
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