26 July 2007 Case of the Week #90


These cases can also be accessed by clicking on the Case of the Week button on the left hand side of our Home Page at www.PathologyOutlines.com. To view the images or references, you must click on the links in blue. Links in green are to journals with free full text-no registration.


This email is sent only to subscribers. To subscribe or unsubscribe, email info@PathologyOutlines.com, indicating subscribe or unsubscribe to Case of the Week. We do not sell, share or use your email address for any other purpose. We also have emails for Pathologist jobs (biweekly), non-pathologist laboratory jobs (biweekly), website news (monthly), new books (monthly), and a newsletter (twice a year). You must subscribe or unsubscribe separately to these email lists.



Visit our New Products and Services page regularly (from the Home Page, click on the button on the left hand side that says New Products or click on the banner above). This page has announcements of interest to pathology personnel, and includes pictures, links and contacts. This is a great way to stay up to date.


We thank Drs. John M. Wayne, Thomas Kocoshis and Howard H. Wu, Ball Memorial Hospital, Muncie, Indiana (USA), for contributing this case. To contribute a Case of the Week, please email info@PathologyOutlines.com with attachments of microscopic images (any size, we will shrink if necessary) in JPG, GIF or TIFF format, a clinical history, your diagnosis and any other images (gross, immunostains, etc.) that may be helpful or interesting. We will write the discussion (unless you want to), list you as the contributor, and send you a check for $35 (US) for your time after we send out the case. Please only send cases with a definitive diagnosis.


Case of the Week #90


Clinical History


A 33 year old woman presented with clinical appendicitis. An appendectomy was performed.


Micro Images: image #1; #2; #3


What is your diagnosis?

























Enterobius vermicularis (pinworm)




The appendix shows no significant acute inflammation, ulceration, granulomas, dysplasia or malignancy. However, there are adults of the species Enterobius vermicularis, with no associated inflammatory reaction.


Enterobius, previously known as Oxyuris vermicularis, is usually identified in the appendix of children ages 7-11 years as an incidental finding. A cluster of worms may cause a mass. There is at most a mild association with appendicitis (Pediatr Surg Int 2004;20:372, Southeast Asian J Trop Med Public Health 2007;38:20)


The diagnosis is usually not difficult, as long as one does not dismiss the worms as vegetable matter. Enterobius is the most common helminthic infection in children, and affects all social strata in the US. The worms reside in the cecum, and average 1.3 cm long. They have prominent lateral spikes on cross section. The eggs are 50 x 20 microns (images), and are often deposited at night on the perianal skin, causing pruritis ani, irritability and loss of sleep. The eggs can be diagnosed with the cellulose tape technique on the perianal skin when the child wakes up. Adult worms may migrate to the lower genital tract and cause a granulomatous reaction.


The differential may include other GI infestations. Ascaris lumbricoides is a common intestinal roundworm, affecting 1 billion people worldwide. It is large, ranging from 15-35 cm, and is usually identified grossly. Unlike Enterobius, it has a smooth cuticle. Its eggs are 60 x 45 microns, with a thick transparent hyaline shell covered by an albuminous coat.


Trichuris trichiura (whipworm) has a whiplike head, and attaches to intestinal mucosa via a long, slender anterior end. The males have coiled tails. The eggs are barrel shaped, 50 x 22 microns, with two polar plugs.


References: Centers for Disease Control



Nat Pernick, M.D., President
PathologyOutlines.com, Inc.

30100 Telegraph Road, Suite 404
Bingham Farms, Michigan (USA) 48025

Telephone: 248/646-0325
Fax: 248/646-1736
Email: NPernick@PathologyOutlines.com