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Coagulation


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Editorial Board oversight: Kyle Annen, D.O. (last reviewed February 2021), Patricia Tsang, M.D., M.B.A. (last reviewed September 2021)
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Table of contents
General:books physiology quality assurance
Acquired bleeding disorders:acquired dysfibrinogenemia acquired von Willebrand disease (AVWD) amyloidosis bovine coagulation factor inhibitors disseminated intravascular coagulation (DIC) Factor V inhibitor Factor VIII inhibitor autoimmune based inhibitors in nonhemophiliac patients Factor IX inhibitor liver dysfunction lupus anticoagulation & antiphospholipid antibodies proteinuria Vitamin K deficiency / Warfarin use
Anticoagulants:4 factor PCC (pending) heparin direct oral anticoagulants (pending) heparin - low molecular weight other anticoagulants & thrombolytic therapy
Hereditary bleeding disorders:hereditary bleeding disorders - general hereditary bleeding disorders - testing algorithm for workup of hereditary bleeding disorders Factor I (fibrinogen) deficiency Factor II (prothrombin) deficiency Factor V deficiency Factor VII deficiency Factor VIII deficiency (hemophilia A) Factor IX deficiency (hemophilia B) Factor X deficiency Factor XI deficiency Factor XII deficiency Factor XIII deficiency high molecular weight kininogen deficiency / assay prekallikrein deficiency von Willebrand disease
Acquired thrombophilia / hypercoagulopathies:acquired thrombophilia - general heparin induced thrombocytopenia (HIT)
Hereditary thrombophilia / hypercoagulopathies:hereditary thrombophilia - general activated protein C resistance / Factor V Leiden antithrombin deficiency dysfibrinogenemia elevated coagulation factor levels in plasma heparin cofactor II deficiency hyperhomocysteinemia protein C deficiency protein S deficiency prothrombin gene mutation (G20210A) / hyperprothrombinemia
Coagulation laboratory tests:abnormal PT and PTT - causes activated clotting time anticardiolipin antibodies antiplasmin assay antithrombin assay bleeding time clot retraction coagulation laboratory tests - overview cryoglobulin / cryofibrinogen assays D-dimer / dimerized plasmin fragment D dabigatran ecarin clotting time factor assays Factor I (fibrinogen) assay Factor V Leiden assay Factor Xa assay heparin induced thrombocytopenia heparinase / heparin contamination assay homocysteine assay hypercoagulation panel International sensitivity index (ISI) low molecular weight heparin (LMWH) mixing studies plasminogen assay plasminogen activator antigen-1 platelet aggregation studies platelet antibodies platelet hyperaggregation studies prekallikrein assay PT - Prothrombin time PT / INR and aPTT reptilase time thrombin time tPA assay validation of assays and instruments (pending) viscoelastic hemostatic assays von Willebrand disease testing
Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:abnormal PT and PTT - causes acquired dysfibrinogenemia acquired thrombophilia - general acquired von Willebrand disease (AVWD) activated clotting time activated protein C resistance / Factor V Leiden algorithm for workup of hereditary bleeding disorders amyloidosis anticardiolipin antibodies antiplasmin assay antithrombin assay antithrombin deficiency autoimmune based inhibitors in nonhemophiliac patients bleeding time bovine coagulation factor inhibitors clot retraction coagulation laboratory tests - overview cryoglobulin / cryofibrinogen assays D-dimer / dimerized plasmin fragment D dabigatran direct oral anticoagulants (pending) disseminated intravascular coagulation (DIC) dysfibrinogenemia ecarin clotting time elevated coagulation factor levels in plasma
F-N:factor assays Factor I (fibrinogen) assay Factor I (fibrinogen) deficiency Factor II (prothrombin) deficiency Factor IX deficiency (hemophilia B) Factor IX inhibitor Factor V deficiency Factor V inhibitor Factor V Leiden assay Factor VII deficiency Factor VIII deficiency (hemophilia A) Factor VIII inhibitor Factor X deficiency Factor Xa assay Factor XI deficiency Factor XII deficiency Factor XIII deficiency heparin heparin - low molecular weight heparin cofactor II deficiency heparin induced thrombocytopenia heparin induced thrombocytopenia (HIT) heparinase / heparin contamination assay hereditary bleeding disorders - general hereditary bleeding disorders - testing hereditary thrombophilia - general high molecular weight kininogen deficiency / assay homocysteine assay hypercoagulation panel hyperhomocysteinemia International sensitivity index (ISI) liver dysfunction low molecular weight heparin (LMWH) lupus anticoagulation & antiphospholipid antibodies mixing studies
O-Z:other anticoagulants & thrombolytic therapy physiology plasminogen activator antigen-1 plasminogen assay platelet aggregation studies platelet antibodies platelet hyperaggregation studies prekallikrein assay prekallikrein deficiency protein C deficiency protein S deficiency proteinuria prothrombin gene mutation (G20210A) / hyperprothrombinemia PT - Prothrombin time PT / INR and aPTT quality assurance reptilase time thrombin time tPA assay validation of assays and instruments (pending) viscoelastic hemostatic assays Vitamin K deficiency / Warfarin use von Willebrand disease von Willebrand disease testing
Other Topics:4 factor PCC (pending)
Coagulation books

Bennett: 2014

Hoffman: 2017

Kaushansky: 2015

Key: 2017

Kottke-Marchant: 2016

McPherson: 2016

Shaz: 2018



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